{"id":"khellin","rwe":[{"pmid":"41857368","year":"2026","title":"Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy.","finding":"","journal":"Acta pharmacologica Sinica","studyType":"Clinical Study"},{"pmid":"41646934","year":"2025","title":"Pharmacological effects and phytochemical profile of methanolic Odontosoria biflora (Kaulf.) C.Chr. [Lindsaeaceae] extract in Caenorhabditis elegans models of Parkinson's disease.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"41369721","year":"2025","title":"Repurposing Ammi visnaga Furanocoumarins as Potent Squalene Epoxidase Inhibitors to Disrupt Lipid Metabolism: An Integrated Phytochemical, In Vitro, and In Silico Study.","finding":"","journal":"Molecular biotechnology","studyType":"Clinical Study"},{"pmid":"41253193","year":"2026","title":"Evaluation of molecular interaction studies of khellin on bovine serum albumin through various biophysical approaches.","finding":"","journal":"Developmental biology","studyType":"Clinical Study"},{"pmid":"40950138","year":"2025","title":"A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform.","finding":"","journal":"bioRxiv : the preprint server for biology","studyType":"Clinical Study"}],"tags":[{"label":"khellin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Cytochrome P450 1A1","category":"target"},{"label":"CYP1A1","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amikellin","offLabel":[],"synonyms":["khellin","amicardien","amicardine","amikellin","khelline","medekellin","methafrone"],"timeline":[],"approvals":[],"brandName":"Amikellin","ecosystem":[],"mechanism":{"target":"Cytochrome P450 1A1","targets":[{"gene":"CYP1A1","source":"DrugCentral","target":"Cytochrome P450 1A1","protein":"Cytochrome P450 1A1"}],"modality":"Small Molecule","drugClass":"khellin","explanation":"Think of it like a traffic cop: the Cytochrome P450 1A1 enzyme helps control the flow of substances through the body's metabolic pathways. Khellin acts like a roadblock, slowing down this process and potentially affecting how certain substances are broken down or used by the body.","oneSentence":"Khellin works by inhibiting the Cytochrome P450 1A1 enzyme, which plays a role in the metabolism of certain substances in the body.","technicalDetail":"Khellin is a competitive inhibitor of the Cytochrome P450 1A1 enzyme, which is involved in the metabolism of various endogenous and exogenous substrates, including certain drugs and environmental toxins."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Khellin","title":"Khellin","extract":"Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. It is a major constituent of the plant Visnaga daucoides, also known as Ammi visnaga and as bishop's weed. Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative. In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current medical practice. Efloxate is also mentioned as analog."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3313","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=KHELLIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Khellin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T12:13:21.340098","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"khellin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167253","NDDF":"006616","UNII":"5G117T0TJZ","CHEBI":"CHEBI:6133","INN_ID":"192","RXNORM":"6147","UMLSCUI":"C0022643","ChEMBL_ID":"CHEMBL44746","PUBCHEM_CID":"3828","SNOMEDCT_US":"63869009","MESH_DESCRIPTOR_UI":"D007666"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":487,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 19","pmid":"41857368","title":"Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy.","journal":"Acta pharmacologica Sinica"},{"date":"2025","pmid":"41646934","title":"Pharmacological effects and phytochemical profile of methanolic Odontosoria biflora (Kaulf.) C.Chr. [Lindsaeaceae] extract in Caenorhabditis elegans models of Parkinson's disease.","journal":"Frontiers in pharmacology"},{"date":"2025 Dec 10","pmid":"41369721","title":"Repurposing Ammi visnaga Furanocoumarins as Potent Squalene Epoxidase Inhibitors to Disrupt Lipid Metabolism: An Integrated Phytochemical, In Vitro, and In Silico Study.","journal":"Molecular biotechnology"},{"date":"2026 Feb","pmid":"41253193","title":"Evaluation of molecular interaction studies of khellin on bovine serum albumin through various biophysical approaches.","journal":"Developmental biology"},{"date":"2025 Sep 4","pmid":"40950138","title":"A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform.","journal":"bioRxiv : the preprint server for biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amikellin is a small molecule with the synonyms AMMIVIN, CORONIN, KELINA, KHELLIN, KHELLINE, and KHELLOYD.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}