{"id":"ketotifen-indomethacin","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Drowsiness (ketotifen)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketotifen prevents mast cell degranulation and blocks histamine H1 receptors to reduce allergic responses, while indomethacin inhibits COX-1 and COX-2 to decrease prostaglandin and leukotriene production. This combination targets both immediate hypersensitivity and inflammatory pathways, potentially useful in allergic and inflammatory conditions.","oneSentence":"Ketotifen is a mast cell stabilizer and H1-receptor antagonist, while indomethacin is a non-selective NSAID that inhibits cyclooxygenase, together reducing allergic inflammation and pain.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:17:53.327Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic conditions (specific indication in phase 3 not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT05007522","phase":"PHASE3","title":"Ketotifen and Indomethacin Combination Treatment Clinical Trial for COVID-19","status":"COMPLETED","sponsor":"Sen-Jam Pharmaceutical","startDate":"2022-05-03","conditions":"COVID-19 Respiratory Infection","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":37,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zaditor","Indocin SR","Tivorbex"],"phase":"phase_3","status":"active","brandName":"Ketotifen/Indomethacin","genericName":"Ketotifen/Indomethacin","companyName":"Sen-Jam Pharmaceutical","companyId":"sen-jam-pharmaceutical","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketotifen is a mast cell stabilizer and H1-receptor antagonist, while indomethacin is a non-selective NSAID that inhibits cyclooxygenase, together reducing allergic inflammation and pain. Used for Allergic conditions (specific indication in phase 3 not publicly detailed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}