{"id":"ketorolac-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Gastrointestinal upset (ketorolac)"},{"rate":null,"effect":"Systemic toxicity from bupivacaine (rare)"},{"rate":null,"effect":"Renal impairment (ketorolac)"}]},"_chembl":{"chemblId":"CHEMBL469","moleculeType":"Small molecule","molecularWeight":"255.27"},"_dailymed":{"setId":"35ffe071-8bc1-4c88-8c85-645847acf169","title":"KETOROCAINE LM KIT (KETOROLAC TROMETHAMINE, LIDOCAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE, POVIDINE IODINE) KIT [ASCLEMED USA, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combination product pairing a systemic NSAID (ketorolac) with a local anesthetic (bupivacaine). Ketorolac works centrally and peripherally by inhibiting cyclooxygenase enzymes, reducing prostaglandin-mediated pain and inflammation. Bupivacaine works locally by reversibly blocking voltage-gated sodium channels in nerve fibers, preventing action potential propagation and providing regional anesthesia. Together they provide multimodal analgesia for acute pain management.","oneSentence":"Ketorolac inhibits prostaglandin synthesis via COX inhibition to reduce pain and inflammation, while bupivacaine blocks sodium channels in nerve membranes to provide local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:47.831Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain management in pediatric patients"},{"name":"Local/regional anesthesia with systemic analgesia"}]},"trialDetails":[{"nctId":"NCT06112548","phase":"NA","title":"The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA","status":"COMPLETED","sponsor":"Damascus University","startDate":"2024-03-01","conditions":"Arthritis Knee, Pain, Arthroplasty Complications","enrollment":80},{"nctId":"NCT07465406","phase":"NA","title":"Postoperative Pain Will be Compared in Cholecystectomy Patients: Half 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