{"id":"ketorolac-0-5-eyedrops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or stinging"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Corneal epithelial defects (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a topical NSAID eyedrop, ketorolac blocks COX-1 and COX-2 enzymes in ocular tissues, reducing the production of inflammatory prostaglandins. This mechanism alleviates ocular pain, inflammation, and photophobia associated with various eye conditions. The 0.5% formulation delivers the drug directly to the anterior segment of the eye for local anti-inflammatory and analgesic effects.","oneSentence":"Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and thereby decrease inflammation and pain in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:08.170Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative ocular pain and inflammation following cataract surgery"},{"name":"Seasonal allergic conjunctivitis"},{"name":"Ocular pain associated with corneal abrasion or refractive surgery"}]},"trialDetails":[{"nctId":"NCT05157113","phase":"PHASE4","title":"Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2022-05-31","conditions":"Cataract, Surgery, Compliance, Patient","enrollment":70},{"nctId":"NCT06616922","phase":"PHASE2","title":"Assessment of the Effects and Tolerability of RD03/2016 for the Treatment of Bacterial Conjunctivitis in Adults","status":"COMPLETED","sponsor":"NTC srl","startDate":"2021-11-05","conditions":"Conjunctivitis, Bacterial","enrollment":252},{"nctId":"NCT06539637","phase":"EARLY_PHASE1","title":"Ketorolac Levels in Vitreous and Aqueous Samples From Patients Undergoing Combined Cataract and Pars Plana Vitrectomy Surgeries With and Without Intracameral Phenylephrine 1.0% / Ketorolac 0.3%","status":"RECRUITING","sponsor":"DHS Consulting","startDate":"2023-09-01","conditions":"Cataract","enrollment":20},{"nctId":"NCT06498440","phase":"PHASE4","title":"Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT","status":"NOT_YET_RECRUITING","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2024-09-01","conditions":"Open Angle Glaucoma, Ocular Hypertension, Postoperative Inflammation","enrollment":126},{"nctId":"NCT00981435","phase":"PHASE4","title":"Steroids After Laser Trabeculoplasty for Glaucoma","status":"COMPLETED","sponsor":"Stanford University","startDate":"2009-09","conditions":"Glaucoma","enrollment":97},{"nctId":"NCT03851172","phase":"PHASE2","title":"Nepafenac Versus Ketorolac Eye Drops in Prevention of Intraoperative Miosis During Cataract Surgery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2019-03-01","conditions":"Cataract, Miosis","enrollment":75},{"nctId":"NCT01769352","phase":"PHASE2, PHASE3","title":"Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1)","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2012-08","conditions":"Post-surgical Cystoid Macular Edema (PSCME)","enrollment":42},{"nctId":"NCT02752646","phase":"NA","title":"Tolerability and Toxicity of Topically Applied Nepafenac 0.3% vs Ketorolac 0.5%","status":"COMPLETED","sponsor":"MDbackline, LLC","startDate":"2016-04","conditions":"Cataract","enrollment":200},{"nctId":"NCT00405730","phase":"PHASE3","title":"Nepafenac 0.1% Eye Drops, Suspension Compared to Ketorolac Trometamol 0.5% Eye Drops, Solution and Placebo","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2005-11","conditions":"Cataracts","enrollment":227},{"nctId":"NCT00478036","phase":"NA","title":"Comparing Acular LS and Pred Forte in Reducing Post-selective Laser Trabeculoplasty Anterior Chamber Flare and Cells","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2007-05","conditions":"Open Angle Glaucoma","enrollment":31},{"nctId":"NCT00485108","phase":"NA","title":"Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty","status":"COMPLETED","sponsor":"Queen's University","startDate":"2007-01","conditions":"Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma","enrollment":120},{"nctId":"NCT02361645","phase":"PHASE3","title":"NSAIDs and PGE2 Levels in Vitrectomy Patients","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2014-03","conditions":"Vitreous Inflammation","enrollment":70},{"nctId":"NCT00904904","phase":"PHASE4","title":"Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2008-04","conditions":"Cataract, Inflammation","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ketorolac 0.5% eyedrops","genericName":"Ketorolac 0.5% eyedrops","companyName":"Università degli Studi di Brescia","companyId":"universit-degli-studi-di-brescia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and thereby decrease inflammation and pain in the eye. Used for Postoperative ocular pain and inflammation following cataract surgery, Seasonal allergic conjunctivitis, Ocular pain associated with corneal abrasion or refractive surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}