{"id":"ketoprofen-matrix-placebo-chadd-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site reactions (erythema, irritation)"},{"rate":null,"effect":"Gastrointestinal upset (if systemic absorption occurs)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketoprofen blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. The transdermal matrix patch formulation delivers ketoprofen through the skin to provide localized and/or systemic anti-inflammatory and analgesic effects. This delivery method aims to reduce systemic exposure compared to oral formulations while maintaining therapeutic efficacy.","oneSentence":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:08.012Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized pain and inflammation (transdermal patch indication, likely musculoskeletal or arthritis-related pain)"}]},"trialDetails":[{"nctId":"NCT00108810","phase":"PHASE2","title":"Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee","status":"COMPLETED","sponsor":"ZARS Pharma Inc.","startDate":"2005-04","conditions":"Pain, Osteoarthritis, Knee","enrollment":118},{"nctId":"NCT00488267","phase":"PHASE3","title":"Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"ZARS Pharma Inc.","startDate":"2007-06","conditions":"Osteoarthritis","enrollment":679}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ketoprofen matrix with no heat"],"phase":"phase_3","status":"active","brandName":"Ketoprofen matrix/placebo CHADD Patch","genericName":"Ketoprofen matrix/placebo CHADD Patch","companyName":"ZARS Pharma Inc.","companyId":"zars-pharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Localized pain and inflammation (transdermal patch indication, likely musculoskeletal or arthritis-related pain).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}