{"id":"ketoprofen-and-cyclobenzaprine-association","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"},{"rate":"null","effect":"Drowsiness"},{"rate":"null","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ketoprofen's mechanism of action involves the inhibition of cyclooxygenase enzymes, specifically COX-1 and COX-2, which are responsible for the production of prostaglandins. Prostaglandins are mediators of inflammation and pain. Cyclobenzaprine, on the other hand, works by affecting the brain's motor control centers, leading to relaxation of skeletal muscles. This results in reduced muscle spasms and pain.","oneSentence":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and inflammation, while cyclobenzaprine is a muscle relaxant that acts as a central nervous system depressant, affecting the brain's motor control centers.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:52.148Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of pain and inflammation"},{"name":"Muscle spasms"}]},"trialDetails":[{"nctId":"NCT03025113","phase":"PHASE3","title":"Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine in Osteomuscular Treatment","status":"COMPLETED","sponsor":"EMS","startDate":"2018-03-08","conditions":"Musculoskeletal Pain","enrollment":416},{"nctId":"NCT02862977","phase":"PHASE3","title":"Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment","status":"COMPLETED","sponsor":"EMS","startDate":"2017-11-10","conditions":"Musculoskeletal Pain","enrollment":414}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["EMS association"],"phase":"phase_3","status":"active","brandName":"ketoprofen and cyclobenzaprine association","genericName":"ketoprofen and cyclobenzaprine association","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and inflammation, while cyclobenzaprine is a muscle relaxant that acts as a central nervous system depressant, affecting the brain's motor control centers. Used for Relief of pain and inflammation, Muscle spasms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}