{"id":"ketoconazole-shampoo-2-week","safety":{"commonSideEffects":[{"rate":null,"effect":"Scalp irritation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dry scalp"},{"rate":null,"effect":"Hair loss (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Ketoconazole is an imidazole antifungal that blocks the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, preventing conversion of lanosterol to ergosterol. This disrupts the integrity of the fungal cell membrane, leading to cell death. When formulated as a topical shampoo, it directly targets Malassezia and other scalp fungi responsible for dandruff and seborrheic dermatitis.","oneSentence":"Ketoconazole shampoo inhibits fungal growth by disrupting ergosterol synthesis in fungal cell membranes, reducing dandruff and seborrheic dermatitis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:07.036Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dandruff and seborrheic dermatitis of the scalp"}]},"trialDetails":[{"nctId":"NCT06170333","phase":"PHASE4","title":"8% Sulphur-Aloe Vera Soap as an Adjuvant Treatment for Pityriasis Versicolor","status":"COMPLETED","sponsor":"Universitas Padjadjaran","startDate":"2023-08-25","conditions":"Pityriasis Versicolor","enrollment":42},{"nctId":"NCT03845348","phase":"PHASE3","title":"To Evaluate the Efficacy and Safety of Shampoo TD03 and TD07 in Scalp Diseases","status":"UNKNOWN","sponsor":"Sao Thai Duong Joint Stock Company","startDate":"2019-05-22","conditions":"Scalp Dermatitis","enrollment":366},{"nctId":"NCT04057950","phase":"NA","title":"Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis","status":"COMPLETED","sponsor":"L'Oreal","startDate":"2019-06-01","conditions":"Scalp Dermatitis, Dermatitis","enrollment":80},{"nctId":"NCT00862654","phase":"PHASE3","title":"Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-03","conditions":"Scalp Seborrheic Dermatitis","enrollment":326},{"nctId":"NCT04007237","phase":"PHASE4","title":"The Comparative Assessment of Mycological Efficacy, Safety, Recurrence, and Cost-effectiveness of Selenium Sulfide 1.8% Shampoo Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: a Double-blind Randomized Controlled Trial","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2018-09-01","conditions":"Pityriasis Versicolor","enrollment":100},{"nctId":"NCT01203189","phase":"NA","title":"Seborrheic Dermatitis: Ketoconazole 2% Foam Versus Ketoconazole 2% Shampoo","status":"COMPLETED","sponsor":"St. Louis University","startDate":"2010-09","conditions":"Seborrheic Dermatitis","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ketoconazole shampoo (2/week)","genericName":"ketoconazole shampoo (2/week)","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoconazole shampoo inhibits fungal growth by disrupting ergosterol synthesis in fungal cell membranes, reducing dandruff and seborrheic dermatitis. Used for Dandruff and seborrheic dermatitis of the scalp.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}