{"id":"ketoconazole-hydrocortisone-and-dutasteride","safety":{"commonSideEffects":[{"rate":"null","effect":"Hepatotoxicity"},{"rate":"null","effect":"Gynecomastia"},{"rate":"null","effect":"Cushing's syndrome"}]},"_chembl":{"chemblId":"CHEMBL1200969","moleculeType":"Small molecule","molecularWeight":"528.54"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ketoconazole works by inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the biosynthesis of ergosterol. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone by blocking the 5α-reductase enzymes. Hydrocortisone exerts its effects by binding to the glucocorticoid receptor, which then translocates to the nucleus and regulates gene expression.","oneSentence":"Ketoconazole is an antifungal that inhibits lanosterol 14α-demethylase, Dutasteride is a 5α-reductase inhibitor, and Hydrocortisone is a corticosteroid that acts as a glucocorticoid receptor agonist.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:58:00.956Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal infections"},{"name":"Benign prostatic hyperplasia"},{"name":"Severe asthma"}]},"trialDetails":[{"nctId":"NCT00953576","phase":"PHASE1, PHASE2","title":"Ketoconazole, Hydrocortisone, Dutasteride and Lapatinib (KHAD-L) in Prostate Cancer","status":"TERMINATED","sponsor":"Dana-Farber Cancer Institute","startDate":"2009-09-29","conditions":"Prostate Cancer","enrollment":11},{"nctId":"NCT00298155","phase":"PHASE2","title":"Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer","status":"COMPLETED","sponsor":"University of Washington","startDate":"2006-07","conditions":"Cancer, Prostate Neoplasms","enrollment":35},{"nctId":"NCT00673127","phase":"PHASE2","title":"Ketoconazole, Hydrocortisone and Dutasteride in Asymptomatic Hormone Refractory Prostate Cancer","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2005-02","conditions":"Prostate Cancer","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dutasteride=Avodart"],"phase":"phase_2","status":"active","brandName":"Ketoconazole, Hydrocortisone and Dutasteride","genericName":"Ketoconazole, Hydrocortisone and Dutasteride","companyName":"Beth Israel Deaconess Medical Center","companyId":"beth-israel-deaconess-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoconazole is an antifungal that inhibits lanosterol 14α-demethylase, Dutasteride is a 5α-reductase inhibitor, and Hydrocortisone is a corticosteroid that acts as a glucocorticoid receptor agonist. Used for Fungal infections, Benign prostatic hyperplasia, Severe asthma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}