{"id":"keto-analogs","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Keto-analogs work by increasing the levels of ketone bodies in the blood, which can help to reduce the need for glucose and improve insulin sensitivity. This can be beneficial for people with type 2 diabetes or those who are at risk of developing it. Additionally, keto-analogs may have anti-inflammatory and anti-cancer properties.","oneSentence":"Keto-analogs are synthetic compounds that mimic the effects of ketone bodies, which are produced by the liver when it breaks down fat for energy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:50.130Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes treatment"}]},"trialDetails":[{"nctId":"NCT07374042","phase":"PHASE3","title":"Ketoanalogue Supplementation for Muscle Protection in CKD 4 and 5 Patients With Moderately Low Protein Diet (KETO-PROT-ACTION)","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2026-01-05","conditions":"Kidney Disease, Chronic","enrollment":100},{"nctId":"NCT06452563","phase":"PHASE4","title":"Amino Acids Supplementation and Exercise Intervention in Hemodialysis Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2024-05-12","conditions":"Hemodialysis Complication, Malnutrition","enrollment":100},{"nctId":"NCT03959228","phase":"PHASE3","title":"Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production","status":"UNKNOWN","sponsor":"Hospices Civils de Lyon","startDate":"2019-11-12","conditions":"Renal Failure","enrollment":50},{"nctId":"NCT01040819","phase":"PHASE4","title":"Does Pioglitazone Increase the Production of 15-EPI-Lipoxin A4?","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2010-02","conditions":"Type 2 Diabetes Mellitus","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"keto-analogs","genericName":"keto-analogs","companyName":"Hospices Civils de Lyon","companyId":"hospices-civils-de-lyon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Keto-analogs are being studied as a potential intervention for various conditions, including kidney disease, renal failure, type 2 diabetes mellitus, and malnutrition, according to ClinicalTrials.gov. Keto-analogs are a type of protein modality, as indicated by ChEMBL, suggesting they may work by interacting with proteins in the body.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}