{"id":"ketazolam","rwe":[],"tags":[{"label":"ketazolam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BA10","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"loftran","offLabel":[],"synonyms":["ketazolam","loftran"],"timeline":[],"approvals":[],"brandName":"Loftran","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ketazolam","explanation":"Think of GABA like a brake pedal in a car. When GABA is released, it helps slow down or calm the activity in the brain. Loftran helps increase the amount of GABA available, which can lead to a calming effect and relief from anxiety or other conditions it may be used to treat.","oneSentence":"Loftran works by enhancing the activity of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain.","technicalDetail":"Ketazolam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride channel opening and resulting in hyperpolarization of the neuronal membrane, which leads to a decrease in neuronal excitability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1525","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=KETAZOLAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:02:51.979101","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"ketazolam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003870","UNII":"92A214MD7Y","CHEBI":"CHEBI:135556","INN_ID":"3107","RXNORM":"28181","UMLSCUI":"C0064304","ChEMBL_ID":"CHEMBL2104356","KEGG_DRUG":"D04650","DRUGBANK_ID":"DB01587","PUBCHEM_CID":"33746","SNOMEDCT_US":"321288000","MESH_SUPPLEMENTAL_RECORD_UI":"C002072"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":41,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA10","allCodes":["N05BA10"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loftran is a small molecule with the synonyms ANSEREN, ANSIETEN, ANXON, CONTAMEX, KETAZOLAM, and KETAZOLAM.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}