{"id":"ketamine-plus-magnesium-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Emergence reactions"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine is a non-competitive NMDA receptor antagonist that produces dissociative anesthesia and analgesia. Magnesium acts as a natural NMDA receptor channel blocker and may potentiate ketamine's effects while reducing excitotoxicity. The combination is being investigated for perioperative anesthesia and analgesia in cancer patients, potentially reducing pain and improving recovery outcomes.","oneSentence":"Ketamine blocks NMDA receptors while magnesium enhances this antagonism and may provide neuroprotective and anti-inflammatory effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:17:46.010Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative anesthesia and analgesia in cancer surgery patients"}]},"trialDetails":[{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT07433231","phase":"NA","title":"Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients","status":"COMPLETED","sponsor":"Ayfer Kaya Gök","startDate":"2023-11-01","conditions":"Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy","enrollment":100},{"nctId":"NCT04275661","phase":"PHASE2","title":"Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-08-01","conditions":"Analgesia, Breast Cancer","enrollment":60},{"nctId":"NCT07381036","phase":"NA","title":"Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2026-02-01","conditions":"Postoperative Sore Throat","enrollment":150},{"nctId":"NCT07248332","phase":"PHASE1","title":"The Efface of Lidocaine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Liaquat National Hospital & Medical College","startDate":"2024-01-18","conditions":"Laparoscopic Cholecystectomy Surgery, Postoperative Pain Management","enrollment":168},{"nctId":"NCT07248358","phase":"PHASE1","title":"The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Liaquat National Hospital & Medical College","startDate":"2023-06-15","conditions":"Laparoscopic Cholecystectomy Surgery, Postoperative Pain Management","enrollment":78},{"nctId":"NCT06985069","phase":"NA","title":"Outcome of Multimodal Anesthesia Bern","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2025-06-16","conditions":"Opioid Use, Pain, Postoperative, Postoperative Complications","enrollment":240},{"nctId":"NCT07131033","phase":"PHASE1, PHASE2","title":"Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Second People's Hospital of Huai'an","startDate":"2025-05-06","conditions":"Laparoscopic Cholecystectomy, Alleviate Postoperative Fatigue Syndrome","enrollment":120},{"nctId":"NCT07075302","phase":"","title":"OFA vs OBA in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital HM Nou Delfos","startDate":"2022-06-01","conditions":"Obesity, Postoperative Pain, Bariatric Surgery","enrollment":70},{"nctId":"NCT04814381","phase":"PHASE4","title":"Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2021-09-15","conditions":"Refractory Chronic Cluster Headache","enrollment":90},{"nctId":"NCT05485480","phase":"NA","title":"Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2022-11-17","conditions":"Analgesia","enrollment":70},{"nctId":"NCT06920576","phase":"PHASE1, PHASE2","title":"Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Second People's Hospital of Huai'an","startDate":"2025-03-01","conditions":"Chronic Rhinosinusitis, Enhanced Recovery After Surgery","enrollment":144},{"nctId":"NCT06915558","phase":"","title":"Modulation of the Inflammatory Response in Bariatric Surgery","status":"RECRUITING","sponsor":"Hospital HM Nou Delfos","startDate":"2024-12-02","conditions":"Obesity, Bariatric Surgery Candidate, Inflammation","enrollment":90},{"nctId":"NCT06414356","phase":"PHASE4","title":"The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD","status":"RECRUITING","sponsor":"Margaux M. Salas, PhD","startDate":"2024-10-02","conditions":"Neuropathic Pain, PTSD","enrollment":30},{"nctId":"NCT05663801","phase":"PHASE2","title":"Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2022-12-01","conditions":"Cancer, Breast","enrollment":72},{"nctId":"NCT06661746","phase":"NA","title":"Efficient Postoperative Pain Management With Multimodal IV","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-07-15","conditions":"Post Operative Pain","enrollment":100},{"nctId":"NCT06427707","phase":"PHASE2, PHASE3","title":"The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-06-15","conditions":"Intraoperative Bleeding","enrollment":90},{"nctId":"NCT05855798","phase":"PHASE4","title":"Ketamine and Magnesium in Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Cukurova University","startDate":"2023-05-10","conditions":"Postoperative Analgesia","enrollment":60},{"nctId":"NCT05752799","phase":"NA","title":"Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids","status":"RECRUITING","sponsor":"G.Gennimatas General Hospital","startDate":"2023-01-01","conditions":"Opioid Use, Unspecified, Bariatric Surgery Candidate","enrollment":70},{"nctId":"NCT05565664","phase":"PHASE4","title":"Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-11-01","conditions":"Post Operative Pain, Acute","enrollment":38},{"nctId":"NCT04360473","phase":"NA","title":"Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia.","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2022-03-14","conditions":"Awakening, Post-Anesthesia Delayed","enrollment":140},{"nctId":"NCT05714540","phase":"PHASE4","title":"Effect of Oropharyngeal Pack Soaked in Ketamine or Magnesium Sulphate on Post Operative Sore Throat After Nasal Surgery","status":"UNKNOWN","sponsor":"Beni-Suef University","startDate":"2023-02-15","conditions":"Sore-throat, Nasopharyngeal Pack, Nasal Surgery","enrollment":90},{"nctId":"NCT05312541","phase":"NA","title":"A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2022-04-10","conditions":"Opioid Free Anesthesia","enrollment":74},{"nctId":"NCT04223219","phase":"PHASE4","title":"Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2019-12-10","conditions":"Coronary Artery Disease, Valve Disease, Heart, Pain, Acute","enrollment":90},{"nctId":"NCT05031676","phase":"NA","title":"Opioid Free Anesthesia in Maxillofacial Surgery","status":"COMPLETED","sponsor":"Université NAZI BONI","startDate":"2019-02-15","conditions":"Maxillofacial Surgery","enrollment":66},{"nctId":"NCT04705948","phase":"NA","title":"Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2020-10-07","conditions":"Postoperative Complications","enrollment":60},{"nctId":"NCT04737473","phase":"NA","title":"The Comparative Efficacy and Safety of Two General Anesthesia Protocols Consisting of Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane for Gynaecology Surgery in Cameroon","status":"UNKNOWN","sponsor":"University of Yaounde 1","startDate":"2020-01-06","conditions":"Opioids, Clinical Trial, Anesthesia","enrollment":36},{"nctId":"NCT04095455","phase":"PHASE3","title":"The Effect Of Ultrasound-guided Modified Pectoral Nerves Block Versus Ketamine Plus Magnesium Infusion On Analgesic Profile In Breast Cancer Surgeries","status":"UNKNOWN","sponsor":"National Cancer Institute, Egypt","startDate":"2017-11-12","conditions":"Postoperative Pain","enrollment":75},{"nctId":"NCT04048200","phase":"PHASE4","title":"The Effect of Opioid Free Anesthesia in Bariatric Surgeries","status":"COMPLETED","sponsor":"Tanta University","startDate":"2019-09-01","conditions":"Adverse Effect of Drugs and Medicaments in Therapeutic Use, Adverse Effects in the Therapeutic Use of Anaesthetics","enrollment":90},{"nctId":"NCT02334059","phase":"NA","title":"Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery","status":"COMPLETED","sponsor":"Milton S. 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