{"id":"ketamine-methadone","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation/hallucinations"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Nausea/vomiting"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Increased heart rate"}]},"_chembl":{"chemblId":"CHEMBL651","moleculeType":"Small molecule","molecularWeight":"309.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine is an NMDA receptor antagonist that produces dissociative anesthesia and has rapid-acting antidepressant properties, while methadone is a synthetic opioid agonist with long half-life and analgesic properties. This combination is used clinically to provide anesthesia, analgesia, and potentially enhanced pain management or psychiatric benefits through complementary mechanisms.","oneSentence":"Ketamine and methadone together provide rapid-acting dissociative anesthesia combined with long-acting opioid analgesia and anti-inflammatory effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:56.438Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance"},{"name":"Acute and chronic pain management"},{"name":"Opioid use disorder (methadone component)"}]},"trialDetails":[{"nctId":"NCT06943859","phase":"PHASE2","title":"Ketamine for Opioid Use Disorder","status":"RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2026-02-04","conditions":"Opioid Use Disorder","enrollment":50},{"nctId":"NCT07365800","phase":"PHASE4","title":"The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.","status":"NOT_YET_RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2026-03-02","conditions":"Spine Surgery","enrollment":248},{"nctId":"NCT06868589","phase":"PHASE4","title":"Reducing Pain With Methadone and Ketamine in Liver Transplant","status":"RECRUITING","sponsor":"Lahey Clinic","startDate":"2025-06-30","conditions":"Liver Transplantation","enrollment":50},{"nctId":"NCT06985069","phase":"NA","title":"Outcome of Multimodal Anesthesia Bern","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2025-06-16","conditions":"Opioid Use, Pain, Postoperative, Postoperative Complications","enrollment":240},{"nctId":"NCT01594047","phase":"NA","title":"Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone","status":"COMPLETED","sponsor":"Fondazione IRCCS Istituto Nazionale dei Tumori, 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Administration for Improved Pain Control in Spinal Fusion Patients","status":"TERMINATED","sponsor":"Montefiore Medical Center","startDate":"2017-07-29","conditions":"Pain, Postoperative","enrollment":10},{"nctId":"NCT02827526","phase":"PHASE4","title":"Methadone and Ketamine for Spinal Surgery","status":"COMPLETED","sponsor":"Endeavor Health","startDate":"2016-07","conditions":"Pain","enrollment":130},{"nctId":"NCT02033707","phase":"PHASE1","title":"Effects of Hallucinogens and Other Drugs on Mood and Performance","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2014-04","conditions":"Healthy","enrollment":20},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034},{"nctId":"NCT00892606","phase":"PHASE4","title":"Methadone Versus Morphine for Orthopedic Surgery Patients","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2009-01","conditions":"Fracture, Pain, Postoperative","enrollment":75},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80},{"nctId":"NCT02233452","phase":"PHASE4","title":"Methadone and Ketamine for Neuropathic Pain Treatment","status":"COMPLETED","sponsor":"Universidade Federal de Santa Maria","startDate":"2012-01","conditions":"Neuropathic Pain","enrollment":37}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ketamine + methadone","genericName":"Ketamine + methadone","companyName":"Cedars-Sinai Medical Center","companyId":"cedars-sinai-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketamine and methadone together provide rapid-acting dissociative anesthesia combined with long-acting opioid analgesia and anti-inflammatory effects. 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