{"id":"kerastat-gel-application","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The gel creates an optimal microenvironment for wound healing by maintaining moisture and potentially delivering growth factors that stimulate keratinocyte proliferation and migration. This promotes re-epithelialization and tissue repair in chronic or acute wounds. The hydrogel formulation allows for sustained release of bioactive components while protecting the wound bed.","oneSentence":"KeraStat® Gel is a topical hydrogel formulation designed to promote wound healing and tissue regeneration by maintaining a moist wound environment and delivering keratinocyte growth factors.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:50:49.484Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic wounds"},{"name":"Acute wounds"},{"name":"Diabetic foot ulcers"}]},"trialDetails":[{"nctId":"NCT04173247","phase":"NA","title":"Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2020-07-27","conditions":"Head and Neck Cancer, Radiation Dermatitis","enrollment":28},{"nctId":"NCT05217160","phase":"PHASE4","title":"Pilot Study: KeraStat® Gel for Topical Delivery of Morphine for Management of Non-Healing, Painful Open Wounds and Ulcers","status":"RECRUITING","sponsor":"The Metis Foundation","startDate":"2021-05-11","conditions":"Wound of Skin, Burns","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"KeraStat® Gel application","genericName":"KeraStat® Gel application","companyName":"The Metis Foundation","companyId":"the-metis-foundation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"KeraStat® Gel is a topical hydrogel formulation designed to promote wound healing and tissue regeneration by maintaining a moist wound environment and delivering keratinocyte growth factors. Used for Chronic wounds, Acute wounds, Diabetic foot ulcers.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}