{"id":"kebuzone","rwe":[{"pmid":"11386636","year":"2001","title":"Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"},{"pmid":"10758780","year":"2000","title":"Binding of kebuzone to human serum albumin studied by high performance liquid affinity chromatography.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"9650370","year":"1998","title":"[HPLC analysis of nonsteroidal antirheumatic agents in biological materials. III. Pyrazolidinediones].","finding":"","journal":"Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti","studyType":"Clinical Study"},{"pmid":"8878255","year":"1996","title":"Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood.","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"8573641","year":"1995","title":"Determination of some non-steroid anti-inflammatory drugs by capillary isotachophoresis.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"}],"tags":[{"label":"kebuzone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ketanol","offLabel":[],"synonyms":["kebuzone","chebutan","chetazol","chetazolidin","ketanol","ketazon","ketazone","ketophenylbutazone"],"timeline":[],"approvals":[],"brandName":"Ketanol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"kebuzone","explanation":"Imagine your body's cells have locks on them, and the key to unlocking the right response is a specific molecule. Ketanol is like a key that fits into one of these locks, allowing the cell to respond in a way that treats the underlying condition. However, the exact lock and key mechanism of Ketanol is still not fully understood.","oneSentence":"Ketanol is thought to work by interacting with a specific molecular target to produce its therapeutic effect.","technicalDetail":"Ketanol is a small molecule that binds to a specific protein target, modulating its activity and producing a therapeutic effect. The precise molecular details of this interaction are currently unknown, but it is believed to involve a reversible binding event that alters the target's function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1522","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=KEBUZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:12:45.692277","biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyphenbutazone","drugSlug":"oxyphenbutazone","fdaApproval":"1960-12-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"kebuzone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"},{"drugId":"oxyphenbutazone","brandName":"oxyphenbutazone","genericName":"oxyphenbutazone","approvalYear":"1960","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004197","UNII":"4VD83UL6Y6","CHEBI":"CHEBI:31749","INN_ID":"2444","RXNORM":"28198","UMLSCUI":"C0064324","ChEMBL_ID":"CHEMBL2107720","KEGG_DRUG":"D01567","DRUGBANK_ID":"DB08940","PUBCHEM_CID":"3824","MESH_SUPPLEMENTAL_RECORD_UI":"C100280"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AA06","allCodes":["M01AA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2001 May-Jun","pmid":"11386636","title":"Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.","journal":"Journal of analytical toxicology"},{"date":"2000 Mar","pmid":"10758780","title":"Binding of kebuzone to human serum albumin studied by high performance liquid affinity chromatography.","journal":"Arzneimittel-Forschung"},{"date":"1998 May","pmid":"9650370","title":"[HPLC analysis of nonsteroidal antirheumatic agents in biological materials. III. Pyrazolidinediones].","journal":"Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti"},{"date":"1996 Sep","pmid":"8878255","title":"Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood.","journal":"Die Pharmazie"},{"date":"1995 Aug","pmid":"8573641","title":"Determination of some non-steroid anti-inflammatory drugs by capillary isotachophoresis.","journal":"Journal of pharmaceutical and biomedical analysis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketanol, also known as Kebuzone, is a small molecule drug in the kebuzone class. Its exact target and mechanism of action are unknown, but it is being developed for an unspecified indication. The commercial status of Ketanol is unclear, and it is not known whether it is patented or available as a generic medication. Further information on its pharmacokinetic properties, such as half-life and bioavailability, is also lacking. As a result, key safety considerations and approved indications for Ketanol remain unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}