{"id":"kanamycin","rwe":[{"pmid":"41900160","year":"2026","title":"Synthesis and Biological Evaluation of Curvularin-Type Derivatives with Potential Anti-Inflammatory, Anticancer, and Antimicrobial Activities.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41879353","year":"2026","title":"Phylogenetic Analysis and In Vitro Evaluation of Probiotic Attributes of Lactobacillus acidophilus and Lactiplantibacillus plantarum Subsp. plantarum Strains Isolated From Fragaria ananassa.","finding":"","journal":"Biotechnology and applied biochemistry","studyType":"Clinical Study"},{"pmid":"41853935","year":"2026","title":"Tn-seq of Thermus thermophilus Genome Reveals Unexpected Tolerance to Insertions in Bacterial Common Essential Genes.","finding":"","journal":"MicrobiologyOpen","studyType":"Clinical Study"},{"pmid":"41848062","year":"2026","title":"Construction of a smartphone-assisted colorimetric nanosensor with multi-antibiotic response based on silver-ceria nanocomposites mimicking peroxidase activity.","finding":"","journal":"The Analyst","studyType":"Clinical Study"},{"pmid":"41846004","year":"2026","title":"Identification of a high-regeneration Malus robusta Rehd. genotype and establishment of an efficient transformation system.","finding":"","journal":"Plant science : an international journal of experimental plant biology","studyType":"Clinical Study"}],"tags":[{"label":"Aminoglycoside Antibacterial","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Gap junction beta-2 protein","category":"target"},{"label":"GJB2","category":"gene"},{"label":"GJA1","category":"gene"},{"label":"A07AA08","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Bacterial pneumonia","category":"indication"},{"label":"Bacterial septicemia","category":"indication"},{"label":"Burn Wound Infections","category":"indication"},{"label":"Cholangitis","category":"indication"},{"label":"Infection of bone","category":"indication"},{"label":"Infection of skin AND/OR subcutaneous tissue","category":"indication"},{"label":"Apothecon","category":"company"},{"label":"Approved 1970s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protein Synthesis Inhibitors","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":88.6,"date":"","count":24,"signal":"Drug resistance","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=89)"}],"drugInteractions":[{"url":"/drug/metocurine","drug":"metocurine","action":"Monitor closely","effect":"May interact with Metocurine Iodide","source":"DrugCentral","drugSlug":"metocurine"},{"url":"/drug/mivacurium","drug":"mivacurium","action":"Monitor closely","effect":"May interact with Mivacurium","source":"DrugCentral","drugSlug":"mivacurium"},{"url":"/drug/pancuronium","drug":"pancuronium","action":"Monitor closely","effect":"May interact with Pancuronium","source":"DrugCentral","drugSlug":"pancuronium"},{"url":"/drug/pipecuronium","drug":"pipecuronium","action":"Monitor closely","effect":"May interact with Pipecuronium","source":"DrugCentral","drugSlug":"pipecuronium"},{"url":"/drug/rocuronium","drug":"rocuronium","action":"Monitor closely","effect":"May interact with Rocuronium Bromide","source":"DrugCentral","drugSlug":"rocuronium"},{"url":"/drug/suxamethonium","drug":"suxamethonium","action":"Monitor closely","effect":"May interact with Succinylcholine","source":"DrugCentral","drugSlug":"suxamethonium"},{"url":"/drug/torsemide","drug":"torsemide","action":"Monitor closely","effect":"May interact with Torsemide","source":"DrugCentral","drugSlug":"torsemide"},{"url":"/drug/tubocurarine","drug":"tubocurarine","action":"Monitor closely","effect":"May interact with Tubocurarine","source":"DrugCentral","drugSlug":"tubocurarine"},{"url":"/drug/vecuronium","drug":"vecuronium","action":"Monitor closely","effect":"May interact with Vecuronium","source":"DrugCentral","drugSlug":"vecuronium"}],"commonSideEffects":[],"contraindications":["Dehydration","Disorder of the 8th Cranial Nerve","Hypocalcemia","Infant Botulism","Kidney disease","Myasthenia gravis","Parkinsonism","Pregnancy, function","Tinnitus","Vertigo"]},"trials":[],"aliases":[],"company":"Bristol-Myers Squibb","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=KANAMYCIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:39:25.234880+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:39:30.848842+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=KANAMYCIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:39:31.053101+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1384/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:39:31.756767+00:00"}},"allNames":"kanacin","offLabel":[],"synonyms":["kanamycin monosulfate","kanamycin a","kanamycin","kanacin","kanamycin sulfate","Kanamycin A sulfate"],"timeline":[{"date":"1973-02-13","type":"positive","source":"DrugCentral","milestone":"FDA approval (Apothecon)"}],"aiSummary":"Kanamycin, also known as Kanacin, is a small molecule aminoglycoside antibacterial drug that targets the gap junction beta-2 protein. It was originally developed by Apothec, and its current owner is also Apothec. Kanamycin was FDA-approved in 1973 for various bacterial infections, including pneumonia, septicemia, and skin infections. The drug has a low bioavailability of 1% and a half-life of 2.1 hours. Kanamycin is available as a generic medication, with 11 generic manufacturers, and is off-patent.","approvals":[{"date":"1973-02-13","orphan":false,"company":"APOTHECON","regulator":"FDA"}],"brandName":"Kanacin","ecosystem":[{"indication":"Bacterial pneumonia","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azithromycin","slug":"azithromycin","company":""}],"globalPrevalence":null},{"indication":"Bacterial septicemia","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azlocillin","slug":"azlocillin","company":"Bayer Pharmaceuticals Corp"}],"globalPrevalence":null},{"indication":"Burn Wound Infections","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"erythromycin ethyl succinate","slug":"erythromycin-ethyl-succinate","company":"Arbor Pharms Llc"},{"name":"gentamicin","slug":"gentamicin","company":"Schering"},{"name":"mafenide","slug":"mafenide","company":"Mylan Institutional"}],"globalPrevalence":null},{"indication":"Cholangitis","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"cefazolin","slug":"cefazolin","company":"Glaxosmithkline"},{"name":"erythromycin ethyl succinate","slug":"erythromycin-ethyl-succinate","company":"Arbor Pharms Llc"}],"globalPrevalence":648000},{"indication":"Infection of bone","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"azlocillin","slug":"azlocillin","company":"Bayer Pharmaceuticals Corp"},{"name":"cefalexin","slug":"cefalexin","company":"Shionogi Inc"},{"name":"cefalotin","slug":"cefalotin","company":"Lilly"}],"globalPrevalence":null},{"indication":"Infection of skin AND/OR subcutaneous tissue","otherDrugs":[{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"}],"globalPrevalence":null},{"indication":"Infectious disease of abdomen","otherDrugs":[{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"}],"globalPrevalence":null},{"indication":"Infectious disorder of joint","otherDrugs":[{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"azlocillin","slug":"azlocillin","company":"Bayer Pharmaceuticals Corp"},{"name":"cefalexin","slug":"cefalexin","company":"Shionogi Inc"},{"name":"cefalotin","slug":"cefalotin","company":"Lilly"}],"globalPrevalence":null}],"mechanism":{"target":"Gap junction beta-2 protein","novelty":"Follow-on","targets":[{"gene":"GJB2","source":"DrugCentral","target":"Gap junction beta-2 protein","protein":"Gap junction beta-2 protein"},{"gene":"GJA1","source":"DrugCentral","target":"Gap junction alpha-1 protein","protein":"Gap junction alpha-1 protein"}],"modality":"Small Molecule","drugClass":"Aminoglycoside Antibacterial","explanation":"","oneSentence":"","technicalDetail":"Kanamycin binds to the 30S subunit of the bacterial ribosome, specifically to the A-site, and causes misreading of mRNA, leading to the incorporation of incorrect amino acids into proteins, ultimately resulting in bacterial cell death."},"commercial":{"launchDate":"1973","_launchSource":"DrugCentral (FDA 1973-02-13, APOTHECON)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1519","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=KANAMYCIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=KANAMYCIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T14:02:46.698685","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:39:33.391882+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic 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septicemia","source":"DrugCentral","snomedId":10001005,"regulator":"FDA"},{"name":"Burn Wound Infections","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Cholangitis","source":"DrugCentral","snomedId":82403002,"regulator":"FDA","usPrevalence":null,"globalPrevalence":648000,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (22245904[PMID])"},{"name":"Infection of bone","source":"DrugCentral","snomedId":111253001,"regulator":"FDA"},{"name":"Infection of skin AND/OR subcutaneous tissue","source":"DrugCentral","snomedId":19824006,"regulator":"FDA"},{"name":"Infectious disease of abdomen","source":"DrugCentral","snomedId":128070006,"regulator":"FDA"},{"name":"Infectious disorder of joint","source":"DrugCentral","snomedId":363162000,"regulator":"FDA"},{"name":"Meningitis","source":"DrugCentral","snomedId":7180009,"regulator":"FDA"},{"name":"Preoperative Bowel Preparation","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Urinary tract infectious disease","source":"DrugCentral","snomedId":68566005,"regulator":"FDA"}],"offLabel":[{"name":"Acute tuberculosis","source":"DrugCentral","drugName":"KANAMYCIN","evidenceCount":23,"evidenceLevel":"moderate"},{"name":"Pulmonary tuberculosis","source":"DrugCentral","drugName":"KANAMYCIN","evidenceCount":510,"evidenceLevel":"strong"}],"pipeline":[]},"drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"nystatin","brandName":"nystatin","genericName":"nystatin","approvalYear":"1964","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"streptomycin","brandName":"streptomycin","genericName":"streptomycin","approvalYear":"1946","relationship":"same-class"},{"drugId":"polymyxin-b","brandName":"Polymyxin B","genericName":"Polymyxin B","approvalYear":"1957","relationship":"same-class"},{"drugId":"paromomycin","brandName":"paromomycin","genericName":"paromomycin","approvalYear":"1969","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin 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