{"id":"k-924-hd","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"K-924 HD acts as a non-steroidal mineralocorticoid receptor antagonist, inhibiting aldosterone-mediated sodium reabsorption in the collecting duct of the kidney. This mechanism reduces fluid volume and blood pressure while potentially preserving potassium levels compared to traditional potassium-sparing diuretics. The drug is being developed for hypertension and heart failure indications.","oneSentence":"K-924 HD is a selective aldosterone antagonist that blocks mineralocorticoid receptor signaling to reduce sodium retention and blood pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:45.156Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure"}]},"trialDetails":[{"nctId":"NCT04289649","phase":"PHASE3","title":"K-924 Phase III Confirmatory Study","status":"COMPLETED","sponsor":"Kowa Company, Ltd.","startDate":"2020-04-02","conditions":"Hypercholesterolemia","enrollment":293},{"nctId":"NCT04289662","phase":"PHASE3","title":"K-924 Phase III Long Term Study","status":"COMPLETED","sponsor":"Kowa Company, Ltd.","startDate":"2020-03-23","conditions":"Hypercholesterolemia","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"K-924 HD","genericName":"K-924 HD","companyName":"Kowa Company, Ltd.","companyId":"kowa-company-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"K-924 HD is a selective aldosterone antagonist that blocks mineralocorticoid receptor signaling to reduce sodium retention and blood pressure. Used for Hypertension, Heart failure.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}