{"id":"jynneos-liquid-formulation","safety":{"commonSideEffects":[{"rate":"48","effect":"Injection site erythema"},{"rate":"41","effect":"Injection site swelling"},{"rate":"24","effect":"Myalgia"},{"rate":"20","effect":"Fatigue"},{"rate":"17","effect":"Headache"},{"rate":"9","effect":"Fever"}]},"_chembl":{"chemblId":"CHEMBL2108930","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains a modified vaccinia Ankara (MVA) virus strain that replicates poorly in human cells but triggers both cellular and humoral immune responses. This primes the immune system to recognize and respond to orthopoxvirus antigens, providing protection against monkeypox and smallpox infection through antibody and T-cell mediated immunity.","oneSentence":"JYNNEOS is a live attenuated vaccinia virus vaccine that stimulates immune responses against orthopoxviruses, including monkeypox and smallpox.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:40.270Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of monkeypox (mpox) in adults at risk of exposure"},{"name":"Prevention of smallpox in at-risk populations"}]},"trialDetails":[{"nctId":"NCT02977715","phase":"PHASE3","title":"JYNNEOS Smallpox Vaccine in Adult Healthcare Personnel at Risk for Mpox in the Democratic Republic of the Congo","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centers for Disease Control and Prevention","startDate":"2017-02-23","conditions":"Monkeypox Virus Infection","enrollment":1600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Modified Vaccinia Ankara (MVA)","MVA-BN","IMVAMUNE","IMVANEX"],"phase":"phase_3","status":"active","brandName":"JYNNEOS (Liquid Formulation)","genericName":"JYNNEOS (Liquid Formulation)","companyName":"Centers for Disease Control and Prevention","companyId":"centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"JYNNEOS is a live attenuated vaccinia virus vaccine that stimulates immune responses against orthopoxviruses, including monkeypox and smallpox. Used for Prevention of monkeypox (mpox) in adults at risk of exposure, Prevention of smallpox in at-risk populations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}