{"id":"josamycin","rwe":[{"pmid":"41457595","year":"2025","title":"[Characterization of cbm2813 encoding the cytochrome P450 enzyme in the biosynthetic gene cluster of carbomycin].","finding":"","journal":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","studyType":"Clinical Study"},{"pmid":"41291582","year":"2025","title":"Epidemiological characteristics of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae, and herpes simplex virus among 5,577 gynecological outpatients in the Xihu district of Hangzhou, China.","finding":"","journal":"BMC women's health","studyType":"Clinical Study"},{"pmid":"41239634","year":"2025","title":"Prevalence and antibiotic resistance of Mycoplasma hominis and Ureaplasma urealyticum in Chongming District, Shanghai, China from 2020 to 2023.","finding":"","journal":"Medicine","studyType":"Clinical Study"},{"pmid":"41174608","year":"2025","title":"Emerging resistance in genital mycoplasmas: 6-year trends of Ureaplasma spp. and Mycoplasma hominis infections in Eastern China.","finding":"","journal":"BMC infectious diseases","studyType":"Clinical Study"},{"pmid":"41113694","year":"2025","title":"Infection Rate and Drug Resistance of Ureaplasma urealyticum and Mycoplasma hominis in Patients With Genital Mycoplasma Infection at the National Hospital of Dermatology and Venereology in Vietnam.","finding":"","journal":"International journal of microbiology","studyType":"Clinical Study"}],"tags":[{"label":"josamycin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01FA07","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"turimycin a5","offLabel":[],"synonyms":["josamycin","Leucomycin A3","iosalide","josacine","josamina","Turimycin A5"],"timeline":[],"approvals":[],"brandName":"Turimycin A5","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"josamycin","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. JOSAMYCIN is like a special tool that blocks the factory's machinery, preventing the bacteria from making the proteins they need to survive. This ultimately leads to the death of the bacterial cells.","oneSentence":"JOSAMYCIN works by binding to the bacterial ribosome and inhibiting the production of essential proteins.","technicalDetail":"JOSAMYCIN binds to the 50S subunit of the bacterial ribosome, specifically to the 23S rRNA, and inhibits the translocation step of protein synthesis, preventing the formation of the peptide bond and ultimately leading to the degradation of the bacterial mRNA."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1518","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=JOSAMYCIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=JOSAMYCIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:59:06.751629","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:15.937077+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"erythromycin","drugSlug":"erythromycin","fdaApproval":"1964-06-24","genericCount":39,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"troleandomycin","drugSlug":"troleandomycin","fdaApproval":"1969-05-27","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clarithromycin","drugSlug":"clarithromycin","fdaApproval":"1991-10-31","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azithromycin","drugSlug":"azithromycin","fdaApproval":"1991-11-01","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dirithromycin","drugSlug":"dirithromycin","fdaApproval":"1995-06-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"telithromycin","drugSlug":"telithromycin","fdaApproval":"2004-04-01","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"josamycin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"erythromycin","brandName":"erythromycin","genericName":"erythromycin","approvalYear":"1964","relationship":"same-class"},{"drugId":"troleandomycin","brandName":"troleandomycin","genericName":"troleandomycin","approvalYear":"1969","relationship":"same-class"},{"drugId":"clarithromycin","brandName":"clarithromycin","genericName":"clarithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"azithromycin","brandName":"azithromycin","genericName":"azithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"dirithromycin","brandName":"dirithromycin","genericName":"dirithromycin","approvalYear":"1995","relationship":"same-class"},{"drugId":"telithromycin","brandName":"telithromycin","genericName":"telithromycin","approvalYear":"2004","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00718705","phase":"PHASE3","title":"Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2008-07","conditions":["Prematurity"],"enrollment":3200,"completionDate":"2011-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000168421","NDDF":"005267","UNII":"HV13HFS217","CHEBI":"CHEBI:31739","INN_ID":"2837","RXNORM":"6084","UMLSCUI":"C0022419","ChEMBL_ID":"CHEMBL224436","KEGG_DRUG":"D01235","DRUGBANK_ID":"DB01321","PDB_CHEM_ID":" JOS","PUBCHEM_CID":"5282165","SNOMEDCT_US":"713477009","MESH_DESCRIPTOR_UI":"D015570"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01FA07","allCodes":["J01FA07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 25","pmid":"41457595","title":"[Characterization of cbm2813 encoding the cytochrome P450 enzyme in the biosynthetic gene cluster of carbomycin].","journal":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology"},{"date":"2025 Nov 25","pmid":"41291582","title":"Epidemiological characteristics of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae, and herpes simplex virus among 5,577 gynecological outpatients in the Xihu district of Hangzhou, China.","journal":"BMC women's health"},{"date":"2025 Nov 14","pmid":"41239634","title":"Prevalence and antibiotic resistance of Mycoplasma hominis and Ureaplasma urealyticum in Chongming District, Shanghai, China from 2020 to 2023.","journal":"Medicine"},{"date":"2025 Oct 31","pmid":"41174608","title":"Emerging resistance in genital mycoplasmas: 6-year trends of Ureaplasma spp. and Mycoplasma hominis infections in Eastern China.","journal":"BMC infectious diseases"},{"date":"2025","pmid":"41113694","title":"Infection Rate and Drug Resistance of Ureaplasma urealyticum and Mycoplasma hominis in Patients With Genital Mycoplasma Infection at the National Hospital of Dermatology and Venereology in Vietnam.","journal":"International journal of microbiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Turimycin A5, also known as JOSAMYCIN, is a small molecule antibiotic belonging to the josamycin class. It is a macrolide antibiotic that works by inhibiting protein synthesis in bacteria, ultimately leading to bacterial cell death. However, its target and exact mechanism of action are unknown. JOSAMYCIN is not approved by the FDA for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to determine its safety and efficacy.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:15.937077+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}