{"id":"jointstem","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient joint effusion"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"JOINTSTEM consists of bone marrow-derived mesenchymal stem cells that are expanded ex vivo and injected directly into the joint. These cells differentiate into chondrocytes and produce anti-inflammatory cytokines, promoting cartilage repair and reducing joint inflammation. The therapy aims to halt or reverse degenerative joint disease through tissue regeneration rather than symptom management alone.","oneSentence":"JOINTSTEM is an autologous mesenchymal stem cell therapy that promotes cartilage regeneration and reduces inflammation in damaged joints.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:36.689Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"}]},"trialDetails":[{"nctId":"NCT04368806","phase":"PHASE2, PHASE3","title":"A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis","status":"RECRUITING","sponsor":"Nature Cell Co. Ltd.","startDate":"2021-05-26","conditions":"Osteoarthritis, Knee","enrollment":140},{"nctId":"NCT04427930","phase":"PHASE3","title":"Follow-up Study for Participants of Jointstem Phase 3 Clinical Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"R-Bio","startDate":"2020-04-13","conditions":"Knee Osteoarthritis","enrollment":129},{"nctId":"NCT03990805","phase":"PHASE3","title":"A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis","status":"COMPLETED","sponsor":"R-Bio","startDate":"2019-06-11","conditions":"Degenerative Arthritis, Knee Osteoarthritis","enrollment":260},{"nctId":"NCT03509025","phase":"PHASE2","title":"Follow-up Study for Participants Jointstem Clinical Trial","status":"COMPLETED","sponsor":"R-Bio","startDate":"2017-02-08","conditions":"Knee Osteoarthritis","enrollment":11},{"nctId":"NCT04825730","phase":"NA","title":"Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"R-Bio","startDate":"2023-12-01","conditions":"Degenerative Arthritis, Knee Arthritis","enrollment":14},{"nctId":"NCT04821102","phase":"NA","title":"Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration","status":"UNKNOWN","sponsor":"R-Bio","startDate":"2023-07-01","conditions":"Degenerative Arthritis, Knee Arthritis","enrollment":21},{"nctId":"NCT02674399","phase":"PHASE2","title":"A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis","status":"COMPLETED","sponsor":"Nature Cell Co. Ltd.","startDate":"2016-02-16","conditions":"Osteoarthritis, Knee","enrollment":28},{"nctId":"NCT03000712","phase":"NA","title":"Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.","status":"COMPLETED","sponsor":"R-Bio","startDate":"2016-11-02","conditions":"Degenerative Arthritis, Knee Osteoarthritis","enrollment":26},{"nctId":"NCT01300598","phase":"PHASE1, PHASE2","title":"Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Degenerative Arthritis","status":"COMPLETED","sponsor":"R-Bio","startDate":"2008-12","conditions":"Degenerative Arthritis","enrollment":18},{"nctId":"NCT02658344","phase":"PHASE2","title":"Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis","status":"COMPLETED","sponsor":"R-Bio","startDate":"2015-07","conditions":"Degenerative Arthritis, Knee Osteoarthritis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["autologous adipose-derived mesenchymal stem cells","Autologous Adipose Tissue derived MSCs","Autologous Adipose Tissue derived MSCs 1x10^8cells/3ml"],"phase":"phase_3","status":"active","brandName":"JOINTSTEM","genericName":"JOINTSTEM","companyName":"R-Bio","companyId":"r-bio","modality":"Small molecule","firstApprovalDate":"","aiSummary":"JOINTSTEM is an autologous mesenchymal stem cell therapy that promotes cartilage regeneration and reduces inflammation in damaged joints. Used for Osteoarthritis of the knee.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":4,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}