{"id":"janus-kinase-inhibitor","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Infections (upper respiratory, urinary tract)"},{"rate":"10-20","effect":"Elevated cholesterol"},{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"5-10","effect":"Hypertension"},{"rate":"1-3","effect":"Thrombosis (venous/arterial)"}]},"_chembl":{"chemblId":"CHEMBL4536936","moleculeType":"Unknown","molecularWeight":"263.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"JAK inhibitors prevent the phosphorylation and activation of STAT proteins downstream of cytokine receptors, thereby suppressing inflammatory cytokine signaling pathways. This reduces the proliferation and activation of immune cells, making them useful for treating autoimmune and inflammatory conditions. 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