{"id":"ivy-leaves-cough-liquid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivy leaves contain saponins and other active compounds that act as expectorants, helping to thin and mobilize respiratory secretions for easier expectoration. The extract also exhibits anti-inflammatory and spasmolytic properties in the airways, reducing cough reflex sensitivity and bronchial irritation. These combined effects make it useful for symptomatic relief of cough associated with respiratory tract conditions.","oneSentence":"Ivy leaves extract promotes mucus clearance and reduces airway inflammation to relieve cough symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:42.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cough associated with respiratory tract conditions"},{"name":"Productive cough relief"}]},"trialDetails":[{"nctId":"NCT06907355","phase":"PHASE4","title":"CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para la TOS","status":"COMPLETED","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2025-05-13","conditions":"Upper Resp Tract Infection","enrollment":196},{"nctId":"NCT06761339","phase":"NA","title":"Clinical Trial Evaluate the Cough-relieving and Expectorant Effects of the Health Supplement AZKA Nasal and Throat for Children in Outpatient-treated Pharyngitis","status":"COMPLETED","sponsor":"Haiphong University of Medicine and Pharmacy","startDate":"2024-12-23","conditions":"Cough Severity, Cough Frequency, Cough Duration","enrollment":24},{"nctId":"NCT02396706","phase":"PHASE2","title":"RCT to Evaluate the Efficacy and Safety of Ivy Leaves Cough Liquid vs. Placebo in the Treatment of Acute Cough","status":"COMPLETED","sponsor":"Engelhard Arzneimittel GmbH & Co.KG","startDate":"2015-01","conditions":"Acute Cough","enrollment":181}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ivy Leaves Cough Liquid","genericName":"Ivy Leaves Cough Liquid","companyName":"Engelhard Arzneimittel GmbH & Co.KG","companyId":"engelhard-arzneimittel-gmbh-co-kg","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ivy leaves extract promotes mucus clearance and reduces airway inflammation to relieve cough symptoms. Used for Cough associated with respiratory tract conditions, Productive cough relief.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}