{"id":"ivm-plus-alb","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, diarrhea, abdominal pain)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivermectin binds to glutamate-gated chloride channels in parasitic nematodes and arthropods, causing paralysis and death. Albendazole inhibits microtubule polymerization in parasites, disrupting their motility and nutrient absorption. The combination targets complementary mechanisms to enhance efficacy against helminthic infections.","oneSentence":"IVM (ivermectin) and ALB (albendazole) are antiparasitic agents that work synergistically to paralyze and kill parasitic worms by disrupting their neuromuscular function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:59.018Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helminthic infections (specific indication under investigation in phase 3 trial at University Hospitals Cleveland Medical Center)"}]},"trialDetails":[{"nctId":"NCT06070116","phase":"PHASE2","title":"Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2024-04-05","conditions":"Onchocercal Subcutaneous Nodule, Onchocerciasis, Onchocerciasis, Ocular","enrollment":300},{"nctId":"NCT06282315","phase":"PHASE3","title":"Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness","status":"RECRUITING","sponsor":"Insud Pharma","startDate":"2025-09-01","conditions":"Soil-Transmitted Helminths","enrollment":20000},{"nctId":"NCT06497075","phase":"","title":"Co-administration of IVM and ALB in School-based Deworming in Uganda","status":"COMPLETED","sponsor":"Jennifer Keiser","startDate":"2024-07-01","conditions":"Helminthiasis, Intestinal Worms","enrollment":8767},{"nctId":"NCT04700423","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration","status":"COMPLETED","sponsor":"Jennifer Keiser","startDate":"2021-03-01","conditions":"Trichuriasis, Ascariasis, Hookworm Infections","enrollment":536},{"nctId":"NCT04285892","phase":"NA","title":"Embryo Developmental Potential in a Novel 2-step IVM System","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2020-07-16","conditions":"In Vitro Maturation of Oocytes","enrollment":23},{"nctId":"NCT04188301","phase":"PHASE2","title":"Safety and Efficacy of IDA for Onchocerciasis","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-12-06","conditions":"Onchocerciasis","enrollment":154},{"nctId":"NCT06037876","phase":"PHASE3","title":"Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura","status":"COMPLETED","sponsor":"Jennifer Keiser","startDate":"2023-10-09","conditions":"Trichuriasis","enrollment":161},{"nctId":"NCT03527732","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of IVM/ALB Co-administration","status":"COMPLETED","sponsor":"Jennifer Keiser","startDate":"2018-09-09","conditions":"Trichuriasis","enrollment":1673},{"nctId":"NCT02974049","phase":"NA","title":"Lymphatic Filariasis (LF) in Ivory Coast","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2015-01","conditions":"Lymphatic Filariasis","enrollment":189},{"nctId":"NCT02845713","phase":"PHASE1","title":"Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE)","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2016-04-17","conditions":"Wuchereria Bancrofti Infection","enrollment":66},{"nctId":"NCT02078024","phase":"PHASE3","title":"Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2014-06","conditions":"Onchocerciasis","enrollment":375},{"nctId":"NCT03921710","phase":"NA","title":"CAPA-IVM Versus STANDARD IVM","status":"COMPLETED","sponsor":"Mỹ Đức Hospital","startDate":"2017-04-29","conditions":"Infertility, Female","enrollment":80},{"nctId":"NCT01975441","phase":"PHASE2","title":"Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2014-05","conditions":"Lymphatic Filariasis","enrollment":182},{"nctId":"NCT03238131","phase":"PHASE3","title":"IVM Alone vs ALB + IVM Against Onchocerciasis","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2012-04","conditions":"Onchocerciasis","enrollment":272}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IVM plus ALB","genericName":"IVM plus ALB","companyName":"University Hospitals Cleveland Medical Center","companyId":"university-hospitals-cleveland-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IVM (ivermectin) and ALB (albendazole) are antiparasitic agents that work synergistically to paralyze and kill parasitic worms by disrupting their neuromuscular function. Used for Helminthic infections (specific indication under investigation in phase 3 trial at University Hospitals Cleveland Medical Center).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}