{"id":"ivf-decapeptyl-and-hcg","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hot flushes"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination is used in controlled ovarian hyperstimulation for in vitro fertilization. Decapeptyl acts as a GnRH agonist to prevent premature luteinizing hormone (LH) surge by initially stimulating then desensitizing GnRH receptors. hCG mimics the natural LH surge to induce final meiotic maturation of oocytes and trigger ovulation, allowing synchronized egg retrieval for fertilization.","oneSentence":"Decapeptyl (triptorelin) suppresses gonadotropin-releasing hormone (GnRH) to downregulate the pituitary-gonadal axis, while hCG (human chorionic gonadotropin) triggers final oocyte maturation and ovulation in assisted reproductive technology.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:59.006Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility requiring in vitro fertilization (IVF) with controlled ovarian hyperstimulation"}]},"trialDetails":[{"nctId":"NCT06732843","phase":"","title":"Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2025-07-23","conditions":"OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte","enrollment":10},{"nctId":"NCT04064840","phase":"PHASE3","title":"GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2019-09-01","conditions":"Subfertility","enrollment":784},{"nctId":"NCT06481696","phase":"NA","title":"Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility","status":"RECRUITING","sponsor":"Andros Day Surgery Clinic","startDate":"2024-06-01","conditions":"Unexplained Infertility","enrollment":90},{"nctId":"NCT04071574","phase":"PHASE1, PHASE2","title":"Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility","status":"COMPLETED","sponsor":"Lebanese University","startDate":"2018-02-01","conditions":"Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure","enrollment":200},{"nctId":"NCT02368964","phase":"NA","title":"IVF Treatment in Women With Immature Oocytes in Previous Cycle","status":"COMPLETED","sponsor":"Sheba Medical Center","startDate":"2015-02-01","conditions":"Infertility","enrollment":100},{"nctId":"NCT00725491","phase":"PHASE3","title":"A Study to Assess the Efficacy and Safety of Ganirelix (Orgalutran®) Treatment in Chinese Women Undergoing Controlled Ovarian Stimulation for in Vitro Fertilization (IVF) or Intra Cytoplasmatic Sperm Injection (ICSI) (Study 38651)(P05703)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-05","conditions":"Controlled Ovarian Stimulation","enrollment":259},{"nctId":"NCT04749979","phase":"NA","title":"Freeze All on Oocyte Maturatin by Gonadotropin Agonist Versus Human Chorionic Gonadotroipin","status":"UNKNOWN","sponsor":"Aljazeera Hospital","startDate":"2021-02-05","conditions":"Infertility","enrollment":100},{"nctId":"NCT03291821","phase":"NA","title":"DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore","status":"COMPLETED","sponsor":"IVI Madrid","startDate":"2017-12-01","conditions":"Infertility, Female","enrollment":136},{"nctId":"NCT04407065","phase":"PHASE2","title":"Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles","status":"UNKNOWN","sponsor":"Riyadh Fertility and Reproductive Health center","startDate":"2020-05-30","conditions":"Infertility, Female","enrollment":56},{"nctId":"NCT04407052","phase":"PHASE2","title":"Double Trigger in Patients With Low Proportion of Mature Oocytes","status":"UNKNOWN","sponsor":"Riyadh Fertility and Reproductive Health center","startDate":"2020-05-30","conditions":"Infertility, Female","enrollment":66},{"nctId":"NCT03809221","phase":"PHASE4","title":"The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation","status":"UNKNOWN","sponsor":"Peking University People's Hospital","startDate":"2019-02-01","conditions":"Infertility, Female","enrollment":1892},{"nctId":"NCT02338206","phase":"PHASE2","title":"Long Protocol and Growth Hormone in Poor Responders","status":"COMPLETED","sponsor":"Woman's Health University Hospital, Egypt","startDate":"2015-03","conditions":"Infertility","enrollment":240},{"nctId":"NCT02053779","phase":"PHASE3","title":"GnRH Agonist Trigger and Modified Luteal Phase Support, Adding a Bolus of GnRHa at the Time of Implantation - a RCT","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Ibn Rochd","startDate":"2014-03","conditions":"Infertility","enrollment":328},{"nctId":"NCT02825290","phase":"PHASE4","title":"Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2016-07","conditions":"Embryo Transfer, Luteal Support","enrollment":62},{"nctId":"NCT02429999","phase":"PHASE2","title":"Letrozole in Assisted Reproductive Technology","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2015-04","conditions":"to Evaluate Letrozole as a Modality for Minimal Ovarian Stimulation in ICSI Cycles .","enrollment":80},{"nctId":"NCT02827656","phase":"NA","title":"Comapring Luteal Phase Support in IVF Patients Who Are at High Risk for Developing OHSS","status":"UNKNOWN","sponsor":"Meir Medical Center","startDate":"2016-08","conditions":"Infertility","enrollment":50},{"nctId":"NCT02813239","phase":"","title":"Dual Triggering in Patients With a High Immature Oocyte Rate","status":"COMPLETED","sponsor":"IVI Madrid","startDate":"2014-11","conditions":"INFERTILITY","enrollment":81},{"nctId":"NCT01897324","phase":"PHASE4","title":"IVF/ICSI Protocols in Poor Responders With Growth Hormone","status":"COMPLETED","sponsor":"Woman's Health University Hospital, Egypt","startDate":"2013-07","conditions":"Female Infertility Due to Diminished Ovarian Reserve","enrollment":287},{"nctId":"NCT02048891","phase":"PHASE4","title":"Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2014-10","conditions":"Infertility","enrollment":3},{"nctId":"NCT02185326","phase":"PHASE4","title":"Microflare Protocol in Poor Responders","status":"COMPLETED","sponsor":"Woman's Health University Hospital, Egypt","startDate":"2014-07","conditions":"Female Infertility Due to Diminished Ovarian Reserve","enrollment":145},{"nctId":"NCT00866008","phase":"PHASE4","title":"A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)","status":"TERMINATED","sponsor":"Bart CJM Fauser","startDate":"2008-10","conditions":"In Vitro Fertilization","enrollment":34},{"nctId":"NCT00985062","phase":"NA","title":"Mild Versus Conventional Ovarian Stimulation Treatment for In Vitro Fertilization","status":"COMPLETED","sponsor":"Erasmus Medical Center","startDate":"2004-10","conditions":"Subfertility","enrollment":54}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IVF: hCG"],"phase":"phase_3","status":"active","brandName":"IVF: Decapeptyl and hCG","genericName":"IVF: Decapeptyl and hCG","companyName":"The University of Hong Kong","companyId":"the-university-of-hong-kong","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Decapeptyl (triptorelin) suppresses gonadotropin-releasing hormone (GnRH) to downregulate the pituitary-gonadal axis, while hCG (human chorionic gonadotropin) triggers final oocyte maturation and ovulation in assisted reproductive technology. Used for Infertility requiring in vitro fertilization (IVF) with controlled ovarian hyperstimulation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}