{"id":"ivermectin-1-cream-ivm","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Burning sensation"}]},"_chembl":{"chemblId":"CHEMBL330828","moleculeType":"Small molecule","molecularWeight":"586.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivermectin is an antiparasitic agent that selectively binds to invertebrate-specific glutamate-gated chloride ion channels, increasing chloride conductance and causing hyperpolarization of nerve and muscle cells. This leads to paralysis and death of susceptible parasites and arthropods. In topical cream formulation, it is used to treat skin conditions caused by parasitic mites and inflammatory responses to parasitic infestation.","oneSentence":"Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:38.378Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rosacea (topical)"},{"name":"Scabies (topical)"}]},"trialDetails":[{"nctId":"NCT02616250","phase":"PHASE4","title":"MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea.","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-12","conditions":"Rosacea","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ivermectin 1% cream (IVM)","genericName":"Ivermectin 1% cream (IVM)","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms. Used for Rosacea (topical), Scabies (topical).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}