{"id":"ivabradine-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Phosphenes (visual symptoms with bright lights)"},{"rate":null,"effect":"Luminopsia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivabradine works by blocking the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels responsible for the funny current in cardiac pacemaker cells. This selective inhibition slows the spontaneous depolarization of the sinoatrial node, thereby reducing heart rate. Unlike beta-blockers and calcium channel blockers, it does not affect myocardial contractility or atrioventricular conduction.","oneSentence":"Ivabradine selectively inhibits the funny current (If) in the sinoatrial node, reducing heart rate without affecting blood pressure or contractility.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:40.779Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic heart failure with reduced ejection fraction (HFrEF) in patients with elevated heart rate"},{"name":"Stable angina pectoris"}]},"trialDetails":[{"nctId":"NCT03168529","phase":"PHASE4","title":"Trial Assessing the Effectiveness of Ivabradine Started at Discharge From the Observation Unit","status":"TERMINATED","sponsor":"Phillip Levy","startDate":"2018-07-01","conditions":"Heart Failure","enrollment":19},{"nctId":"NCT06670690","phase":"NA","title":"Comparison Between Atenolol,Propnalol and Ivabradine","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2023-09-01","conditions":"Intraoperative Bleeding","enrollment":120},{"nctId":"NCT04436016","phase":"PHASE4","title":"PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2020-10-05","conditions":"Myocardial Injury, Myocardial Ischemia","enrollment":78},{"nctId":"NCT03182725","phase":"PHASE3","title":"Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2018-02-06","conditions":"Postural Orthostatic Tachycardia Syndrome","enrollment":37},{"nctId":"NCT03245996","phase":"PHASE4","title":"The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker","status":"COMPLETED","sponsor":"Tartu University Hospital","startDate":"2015-06","conditions":"Aortic Blood Pressure","enrollment":27},{"nctId":"NCT02236247","phase":"PHASE1, PHASE2","title":"Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2013-05","conditions":"Decompensated Heart Failure","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ivabradine Pill","genericName":"Ivabradine Pill","companyName":"Tartu University Hospital","companyId":"tartu-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ivabradine selectively inhibits the funny current (If) in the sinoatrial node, reducing heart rate without affecting blood pressure or contractility. Used for Chronic heart failure with reduced ejection fraction (HFrEF) in patients with elevated resting heart rate, Stable angina pectoris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}