{"id":"iv-titration-of-morphine-chlorhydrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL5665374","moleculeType":null,"molecularWeight":"285.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the spinal cord and brain to modulate pain perception and emotional response to pain. IV titration allows for rapid onset and precise dose adjustment to achieve desired analgesia while minimizing overdose risk. This formulation is commonly used for acute severe pain management in hospital settings.","oneSentence":"Morphine binds to opioid receptors in the central nervous system to produce analgesia and sedation through inhibition of pain signal transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:28.542Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute severe pain in hospitalized patients"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT03257319","phase":"PHASE3","title":"Inhaled vs IV Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2017-09-19","conditions":"Pain, Acute, Emergencies, Morphine","enrollment":226}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inhaled placebo"],"phase":"phase_3","status":"active","brandName":"IV titration of morphine chlorhydrate","genericName":"IV titration of morphine chlorhydrate","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine binds to opioid receptors in the central nervous system to produce analgesia and sedation through inhibition of pain signal transmission. Used for Acute severe pain in hospitalized patients, Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}