{"id":"iv-n-acetyl-cystein","safety":{"commonSideEffects":[{"rate":"5–15","effect":"Nausea and vomiting"},{"rate":"5–10","effect":"Flushing and facial erythema"},{"rate":"1–5","effect":"Anaphylactoid reactions"},{"rate":"2–8","effect":"Rash and pruritus"},{"rate":"1–3","effect":"Bronchospasm"}]},"_chembl":{"chemblId":"CHEMBL1778338","moleculeType":"Small molecule","molecularWeight":"191.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NAC is a precursor to the tripeptide glutathione, a major cellular antioxidant that neutralizes reactive oxygen species and free radicals. By restoring depleted glutathione pools, NAC protects cells from oxidative damage, reduces inflammatory cytokine production, and may enhance mucosal and tissue repair. IV administration provides rapid systemic bioavailability for acute conditions where oral absorption is insufficient.","oneSentence":"N-Acetyl Cysteine (NAC) replenishes intracellular glutathione and acts as a potent antioxidant to reduce oxidative stress and inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:27.251Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acetaminophen (paracetamol) overdose and hepatotoxicity prevention"},{"name":"Acute respiratory distress syndrome (ARDS)"},{"name":"Chronic obstructive pulmonary disease (COPD) exacerbations"},{"name":"Cystic fibrosis"}]},"trialDetails":[{"nctId":"NCT01820195","phase":"PHASE3","title":"N-Acetyl Cystein and Contrast Nephropathy","status":"UNKNOWN","sponsor":"Imam Khomeini Hospital","startDate":"2013-03","conditions":"Chronic Kidney Disease Stage 2, Radiographic Contrast Agent Nephropathy","enrollment":549}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IV N-Acetyl Cystein","genericName":"IV N-Acetyl Cystein","companyName":"Imam Khomeini Hospital","companyId":"imam-khomeini-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"N-Acetyl Cysteine (NAC) replenishes intracellular glutathione and acts as a potent antioxidant to reduce oxidative stress and inflammation. Used for Acetaminophen (paracetamol) overdose and hepatotoxicity prevention, Acute respiratory distress syndrome (ARDS), Chronic obstructive pulmonary disease (COPD) exacerbations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}