{"id":"iv-loop-diuretic","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (with high doses)"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL3121562","moleculeType":"Small molecule","molecularWeight":"784.98"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Loop diuretics block the sodium-potassium-chloride cotransporter (NKCC2) on the apical membrane of thick ascending limb cells, preventing reabsorption of approximately 20-30% of filtered sodium and water. This results in increased urine production and reduced blood volume and intracardiac filling pressures. IV formulations provide rapid onset of action, making them suitable for acute decompensated heart failure and pulmonary edema.","oneSentence":"IV loop diuretics inhibit the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium and water reabsorption to increase urine output.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:31.078Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute decompensated heart failure with fluid overload"},{"name":"Pulmonary edema"},{"name":"Edema associated with renal disease or hepatic cirrhosis"}]},"trialDetails":[{"nctId":"NCT07077772","phase":"NA","title":"Natriuresis-guided Depletion After Cardiac Surgery","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2025-06-25","conditions":"Cardiac Surgery, Diuresis, Congestion, Venous","enrollment":102},{"nctId":"NCT02546583","phase":"PHASE1","title":"Diagnosing and Targeting Mechanisms of 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Used for Acute decompensated heart failure with fluid overload, Pulmonary edema, Edema associated with renal disease or hepatic cirrhosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}