{"id":"iv-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Increased blood pressure"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, a major excitatory glutamate receptor in the central nervous system. This mechanism produces dissociation, analgesia, and sedation. In psychiatric applications, particularly for treatment-resistant depression, ketamine's rapid antidepressant effects are thought to involve downstream signaling cascades including mTOR pathway activation and increased synaptic plasticity, distinct from traditional monoamine-based antidepressants.","oneSentence":"IV ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset dissociative and analgesic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:25.294Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment-resistant depression"},{"name":"Acute suicidal ideation and behavior"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT03336398","phase":"PHASE2","title":"Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2019-09-01","conditions":"Tinnitus","enrollment":42},{"nctId":"NCT06903819","phase":"PHASE4","title":"Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients","status":"RECRUITING","sponsor":"Texas Tech University Health Sciences Center","startDate":"2025-11-06","conditions":"Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use","enrollment":90},{"nctId":"NCT07490457","phase":"NA","title":"Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","status":"NOT_YET_RECRUITING","sponsor":"Bursa City Hospital","startDate":"2026-04-15","conditions":"Cardiac Anaesthesia, Chronic Pain, Post Operative Pain, Chronic","enrollment":100},{"nctId":"NCT07476482","phase":"NA","title":"The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia","status":"ENROLLING_BY_INVITATION","sponsor":"Alexandria University","startDate":"2026-04-01","conditions":"Decision Making , Cesarean Section","enrollment":80},{"nctId":"NCT07248202","phase":"NA","title":"Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia","enrollment":40},{"nctId":"NCT06781697","phase":"PHASE3","title":"InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression","status":"NOT_YET_RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2026-05","conditions":"Treatment Resistant Depression","enrollment":31},{"nctId":"NCT07443254","phase":"PHASE1, PHASE2","title":"Prospective IR-led Sedation Feasibility","status":"RECRUITING","sponsor":"CAMC Health System","startDate":"2026-03-02","conditions":"Anesthesia, Sedation and Analgesia, Interventional Radiology","enrollment":40},{"nctId":"NCT05437575","phase":"PHASE3","title":"Prehospital Analgesia INtervention Trial (PAIN)","status":"RECRUITING","sponsor":"Jason Sperry","startDate":"2023-11-27","conditions":"Traumatic Injury","enrollment":994},{"nctId":"NCT07369024","phase":"PHASE2","title":"Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults","status":"RECRUITING","sponsor":"Mohsen Saidinejad","startDate":"2026-04-01","conditions":"Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Ketamine Infusion","enrollment":120},{"nctId":"NCT05597878","phase":"PHASE2, PHASE3","title":"Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy","status":"SUSPENDED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-04-18","conditions":"Pain Management, Opioid Use, Prostate Cancer","enrollment":100},{"nctId":"NCT07455565","phase":"NA","title":"Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Akdeniz University Hospital","startDate":"2025-12-16","conditions":"Postoperative Pain, Lumbar Spine Surgery","enrollment":100},{"nctId":"NCT06620276","phase":"NA","title":"ACT_for Alcohol Use Disorder and Depression","status":"RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2025-05-01","conditions":"Depression - 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