{"id":"iv-furosemide-and-iv-acetazolamide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Ototoxicity (furosemide)"},{"rate":null,"effect":"Metabolic acidosis (acetazolamide)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hyperuricemia"}]},"_chembl":{"chemblId":"CHEMBL3121562","moleculeType":"Small molecule","molecularWeight":"784.98"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium and chloride and producing potent diuresis. Acetazolamide inhibits carbonic anhydrase in the proximal tubule, reducing bicarbonate reabsorption and promoting sodium and water excretion. Together, they provide synergistic diuretic and natriuretic effects, often used in resistant edema or acute decompensated heart failure.","oneSentence":"This combination uses furosemide (a loop diuretic) to increase urine output and acetazolamide (a carbonic anhydrase inhibitor) to promote bicarbonate and electrolyte excretion, together enhancing diuresis and reducing fluid overload.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:26.439Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute decompensated heart failure with fluid overload"},{"name":"Resistant edema"},{"name":"Pulmonary edema"}]},"trialDetails":[{"nctId":"NCT05470283","phase":"PHASE1","title":"Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2022-09-07","conditions":"Tumor, Metastatic Melanoma, Melanoma","enrollment":21},{"nctId":"NCT06092437","phase":"NA","title":"Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients","status":"RECRUITING","sponsor":"Zuyderland Medisch Centrum","startDate":"2023-02-27","conditions":"Heart Failure Acute","enrollment":466},{"nctId":"NCT06362668","phase":"NA","title":"EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU)","status":"COMPLETED","sponsor":"Reprieve Cardiovascular, Inc","startDate":"2024-05-17","conditions":"Acute Decompensated Heart Failure","enrollment":12},{"nctId":"NCT06535529","phase":"PHASE3","title":"Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients","status":"RECRUITING","sponsor":"Helwan University","startDate":"2024-08-24","conditions":"Acute Decompensated Heart Failure","enrollment":60},{"nctId":"NCT06414759","phase":"PHASE4","title":"Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-07-01","conditions":"Acute Decompensated Heart Failure, Volume Overload, Edema","enrollment":110},{"nctId":"NCT05904808","phase":"PHASE4","title":"The Heart Failure Diuresis Efficacy Comparison (DEA-HF) Study","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2023-04-19","conditions":"Chronic Heart Failure, Diuretics Drug Reactions, Congestive Heart Failure","enrollment":42},{"nctId":"NCT05940220","phase":"PHASE3","title":"Efficacy of Oral Acetazolamide in Decongestion in Patients With Heart Failure","status":"UNKNOWN","sponsor":"Tehran University of Medical Sciences","startDate":"2023-12-30","conditions":"Heart Failure","enrollment":130}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Oral Magnesium citrate 600mg"],"phase":"marketed","status":"active","brandName":"IV Furosemide and IV Acetazolamide","genericName":"IV Furosemide and IV Acetazolamide","companyName":"Rambam Health Care Campus","companyId":"rambam-health-care-campus","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses furosemide (a loop diuretic) to increase urine output and acetazolamide (a carbonic anhydrase inhibitor) to promote bicarbonate and electrolyte excretion, together enhancing diuresis and reducing fluid overload. Used for Acute decompensated heart failure with fluid overload, Resistant edema, Pulmonary edema.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}