{"id":"iv-efgartigimod","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection (including upper respiratory tract infection)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Efgartigimod binds to the neonatal Fc receptor (FcRn) on endothelial cells, preventing the recycling and prolonging the half-life of IgG antibodies. This leads to increased catabolism and reduced serum levels of pathogenic IgG antibodies. In autoimmune conditions mediated by IgG, lowering circulating IgG levels reduces disease activity.","oneSentence":"Efgartigimod is an IgG Fc receptor inhibitor that reduces circulating immunoglobulin G (IgG) antibodies by blocking their recycling through the neonatal Fc receptor (FcRn).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:35.202Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Generalized myasthenia gravis (gMG)"}]},"trialDetails":[{"nctId":"NCT07217587","phase":"PHASE3","title":"Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2026-01-05","conditions":"Myasthenia Gravis","enrollment":115},{"nctId":"NCT06544499","phase":"PHASE3","title":"A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia","status":"RECRUITING","sponsor":"argenx","startDate":"2024-10-18","conditions":"Primary Immune Thrombocytopenia (ITP)","enrollment":69},{"nctId":"NCT07194850","phase":"PHASE2, PHASE3","title":"A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP)","status":"RECRUITING","sponsor":"argenx","startDate":"2025-10-20","conditions":"Immune Thrombocytopenia (ITP), ITP - 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