{"id":"iv-dexmedetomidine","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Hypotension"},{"rate":"10-25","effect":"Bradycardia"},{"rate":"5-15","effect":"Hypertension (transient, initial)"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Rebound hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds with high selectivity to alpha-2 adrenergic receptors, which are distributed throughout the brain and spinal cord. This activation leads to decreased norepinephrine release and reduced neuronal firing, resulting in sedative and analgesic effects. The drug produces a unique sedation profile characterized by maintained airway reflexes and the ability to be aroused, distinguishing it from other sedatives.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic receptor agonist that produces sedation, analgesia, and anxiolysis by activating presynaptic and postsynaptic alpha-2 receptors in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:27.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation in intensive care unit patients"},{"name":"Perioperative sedation and analgesia"},{"name":"Procedural sedation"}]},"trialDetails":[{"nctId":"NCT07497009","phase":"NA","title":"Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial.","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-12-23","conditions":"Neurocognitive Function of Elderly Patients Post Operation","enrollment":30},{"nctId":"NCT07184801","phase":"PHASE3","title":"Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy","status":"RECRUITING","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2025-10-01","conditions":"Medical Thoracoscopy","enrollment":56},{"nctId":"NCT06936410","phase":"PHASE2","title":"Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-03-01","conditions":"Tourniquet Hypertension","enrollment":186},{"nctId":"NCT07475156","phase":"PHASE4","title":"The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2025-08-01","conditions":"Post Operative Delerium","enrollment":100},{"nctId":"NCT07460310","phase":"NA","title":"Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-03-01","conditions":"Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management","enrollment":200},{"nctId":"NCT07434206","phase":"PHASE2, PHASE3","title":"Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"South Egypt Cancer Institute","startDate":"2024-04-25","conditions":"Thyroid Neoplasms","enrollment":80},{"nctId":"NCT07425444","phase":"PHASE4","title":"Attenuate the Stress Response in Laparoscopic Cholecystectomy","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-02","conditions":"Laparoscopic Cholecystectomy Surgery","enrollment":50},{"nctId":"NCT07211399","phase":"EARLY_PHASE1","title":"Transition From Acute to Chronic Opioid Use and Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. 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