{"id":"iv-casopitant-gw679769","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Casopitant selectively antagonizes the NK1 receptor, which is a key mediator of nausea and vomiting pathways in the central nervous system. By blocking substance P binding to NK1 receptors, it prevents both acute and delayed emetic responses triggered by chemotherapy. This mechanism complements 5-HT3 antagonists and corticosteroids in multimodal antiemetic regimens.","oneSentence":"Casopitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent chemotherapy-induced nausea and vomiting.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:58.030Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy"}]},"trialDetails":[{"nctId":"NCT00601172","phase":"PHASE3","title":"A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-03-10","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":710},{"nctId":"NCT00334646","phase":"PHASE1","title":"Cyclophosphamide Drug Interaction Study In Cancer Patients","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2005-08-10","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":25},{"nctId":"NCT00437229","phase":"PHASE1","title":"A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-02-19","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":37},{"nctId":"NCT00431236","phase":"PHASE3","title":"A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-11-06","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":810},{"nctId":"NCT00891761","phase":"PHASE3","title":"A Study of IV Casopitant for the Prevention of Nausea and Vomiting Caused By Cisplatin-Based Highly Emetogenic Chemotherapy","status":"WITHDRAWN","sponsor":"GlaxoSmithKline","startDate":"2009-09","conditions":"Cancer, Chemotherapy-Induced Nausea and Vomiting, Nausea and Vomiting","enrollment":""},{"nctId":"NCT00366834","phase":"PHASE3","title":"Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-07","conditions":"Vomiting, Nausea, Nausea and Vomiting, Chemotherapy-Induced","enrollment":1840}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IV Casopitant (GW679769)","genericName":"IV Casopitant (GW679769)","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Casopitant is a neurokinin-1 (NK1) receptor antagonist that blocks substance P signaling in the chemoreceptor trigger zone and vomiting center to prevent chemotherapy-induced nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}