{"id":"isoxepac","rwe":[{"pmid":"38329183","year":"2024","title":"Photoinduced selective perfluoroalkylation of terminal alkynes via electron donor-acceptor complexes.","finding":"","journal":"Chemical communications (Cambridge, England)","studyType":"Clinical Study"},{"pmid":"34628862","year":"2021","title":"Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"36703482","year":"2020","title":"Pd-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine.","finding":"","journal":"Communications chemistry","studyType":"Clinical Study"},{"pmid":"28926269","year":"2017","title":"Hypervalent-Iodine-Mediated Ring-Contraction Monofluorination Affording Monofluorinated Five-Membered Ring-Fused Oxazolines.","finding":"","journal":"Organic letters","studyType":"Clinical Study"},{"pmid":"7040500","year":"1982","title":"Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial.","finding":"","journal":"Journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"isoxepac","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"contraindications":["Disease of liver"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"artil","offLabel":[],"synonyms":["isoxepac","artil"],"timeline":[],"approvals":[],"brandName":"Artil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"isoxepac","explanation":"Imagine your body's cells have locks on them, and Artil is a key that fits into one of those locks. When it binds to the lock, it triggers a series of events that help to treat a particular condition. This is a simplified explanation of how Artil works at a molecular level.","oneSentence":"Artil works by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Artil's exact mechanism of action is not publicly disclosed, but as a small molecule isoxepac, it is likely to interact with a specific protein or receptor to produce its therapeutic effect."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Artil","title":"Artil","extract":"Artil is a village in Sanhan District of Sanaa Governorate, Yemen. It is located 2 km due south of Bayt Baws.","wiki_history":"== History ==\nThe first known mention of is in the Ghāyat al-amānī, by Yahya ibn al-Husayn, which says that during Shawwal of 290 AH (August–September 903), Ali ibn al-Husay Khuftum, the former Abbasid governor of Sanaa, stayed at Artil for six days before being taken captive here and then imprisoned at Bayt Baws. According to Robert T.O. Wilson, Artil was used as \"a base for movements against Sanaa rather than a fortifiable and defensible position\" during this period."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3310","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ISOXEPAC","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Artil","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:01:40.353415","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"isoxepac","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"2KH283Q0Z5","CHEBI":"CHEBI:135102","INN_ID":"4246","UMLSCUI":"C0064103","ChEMBL_ID":"CHEMBL33211","KEGG_DRUG":"D04638","PUBCHEM_CID":"41448","MESH_SUPPLEMENTAL_RECORD_UI":"C014904"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Feb 27","pmid":"38329183","title":"Photoinduced selective perfluoroalkylation of terminal alkynes via electron donor-acceptor complexes.","journal":"Chemical communications (Cambridge, England)"},{"date":"2021 Nov 5","pmid":"34628862","title":"Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives.","journal":"The Journal of organic chemistry"},{"date":"2020 May 11","pmid":"36703482","title":"Pd-catalyzed fluoro-carbonylation of aryl, vinyl, and heteroaryl iodides using 2-(difluoromethoxy)-5-nitropyridine.","journal":"Communications chemistry"},{"date":"2017 Oct 6","pmid":"28926269","title":"Hypervalent-Iodine-Mediated Ring-Contraction Monofluorination Affording Monofluorinated Five-Membered Ring-Fused Oxazolines.","journal":"Organic letters"},{"date":"1982 Feb-Mar","pmid":"7040500","title":"Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial.","journal":"Journal of clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Artil (ISOXEPAC) is a small molecule isoxepac drug with unknown target and commercial status. Its mechanism of action is not publicly disclosed, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its pharmacokinetics, safety, and efficacy. Further research is needed to understand its potential therapeutic applications and risks. Due to the lack of publicly available data, Artil's status as a patented or generic drug, and its approved indications, if any, remain unknown.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}