{"id":"isotretinoin-roaccutane","safety":{"commonSideEffects":[{"rate":"90","effect":"Cheilitis (lip inflammation)"},{"rate":"80","effect":"Dry skin and mucous membranes"},{"rate":"25-40","effect":"Elevated triglycerides"},{"rate":"15-20","effect":"Elevated liver enzymes"},{"rate":"10-15","effect":"Headache"},{"rate":"10","effect":"Photosensitivity"},{"rate":"high risk","effect":"Teratogenicity (if exposed during pregnancy)"}]},"_chembl":{"chemblId":"CHEMBL2107427","moleculeType":"Small molecule","molecularWeight":"448.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isotretinoin is a synthetic form of vitamin A that binds to retinoid receptors in the nucleus, regulating gene expression involved in cell differentiation and proliferation. It dramatically reduces sebaceous gland size and sebum secretion, decreases bacterial colonization, and has immunomodulatory and anti-inflammatory properties. 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