{"id":"isotone-saline-water","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hyponatremia (with excessive use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isotonic saline (0.9% sodium chloride) is a crystalloid solution with osmolarity matching that of blood plasma, allowing it to distribute between intracellular and extracellular compartments without causing cellular water shifts. It is used for fluid resuscitation, maintenance therapy, and as a vehicle for drug administration. The solution restores intravascular volume and corrects dehydration while maintaining normal electrolyte balance.","oneSentence":"Isotonic saline water provides osmotically balanced fluid replacement to maintain cellular hydration and electrolyte homeostasis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:21.191Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid resuscitation and maintenance in dehydration"},{"name":"Perioperative fluid management"},{"name":"Vehicle for intravenous drug administration"}]},"trialDetails":[{"nctId":"NCT04857671","phase":"PHASE3","title":"Botulinum Toxin A in Frequent and Chronic Tension-type Headache","status":"COMPLETED","sponsor":"Helse Nord-Trøndelag HF","startDate":"2022-10-03","conditions":"Tension-Type Headache","enrollment":66},{"nctId":"NCT06805448","phase":"PHASE1, PHASE2","title":"Intraglandular Treatment With Adipose-derived Mesenchymal Stem Cells in Patients With Xerostomia Due to Sjögren's Disease","status":"RECRUITING","sponsor":"Rigshospitalet, Denmark","startDate":"2025-01-21","conditions":"Sjorgren's Syndrome","enrollment":40},{"nctId":"NCT03543254","phase":"PHASE2","title":"\"Follow the Sutures\". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2018-05-01","conditions":"Migraine Disorders, Chronic Disease","enrollment":20},{"nctId":"NCT01486550","phase":"PHASE4","title":"Hydroxyethyl Starch and Renal Function After Laparoscopic Nephrectomy","status":"TERMINATED","sponsor":"Regional Hospital Holstebro","startDate":"2011-12","conditions":"Kidney Cancer","enrollment":14},{"nctId":"NCT01486576","phase":"PHASE4","title":"Hydroxyethyl Starch and Renal Function After Hip Replacement Surgery","status":"COMPLETED","sponsor":"Regional Hospital Holstebro","startDate":"2012-01","conditions":"Osteoarthritis","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sodium chloride solution","NaCl solution"],"phase":"phase_3","status":"active","brandName":"Isotone saline water","genericName":"Isotone saline water","companyName":"Helse Nord-Trøndelag HF","companyId":"helse-nord-tr-ndelag-hf","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isotone saline water is a type of saline solution that is chemically classified as a small molecule. It has been used as a control intervention in clinical trials studying various conditions, including Sjögren's Syndrome, Kidney Cancer, Osteoarthritis, Tension-Type Headache, and Migraine Disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}