{"id":"isothipendyl","rwe":[{"pmid":"32124458","year":"2020","title":"Photodermatitis from topical phenothiazines: A case series.","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"},{"pmid":"22677929","year":"2012","title":"Contact photoallergy to isothipendyl chlorhydrate.","finding":"","journal":"Dermatology (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"14723280","year":"2003","title":"Spectrophotometric studies on the investigation of chromium in environmental samples.","finding":"","journal":"Indian journal of environmental health","studyType":"Clinical Study"},{"pmid":"12675360","year":"2003","title":"Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations.","finding":"","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry","studyType":"Clinical Study"},{"pmid":"11708072","year":"2001","title":"Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples.","finding":"","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry","studyType":"Clinical Study"}],"tags":[{"label":"isothipendyl","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D04AA22","category":"atc"},{"label":"Active","category":"status"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dimethylaminoisopropylazaphenothiazine","offLabel":[],"synonyms":["isothipendyl","dimethylaminoisopropylazaphenothiazine","isothipendyl hydrochloride","isothipendyl HCl"],"timeline":[],"approvals":[],"brandName":"Dimethylaminoisopropylazaphenothiazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"isothipendyl","explanation":"Imagine your body's cells have locks on them, and isothipendyl is a key that fits into one of those locks. When it binds to the lock, it can either turn the lock open or closed, depending on the type of lock and the key's shape. This can affect how the cell behaves and responds to signals, but the exact details of how isothipendyl works are still being studied.","oneSentence":"Isothipendyl is thought to work by interacting with a specific molecular target, although its exact mechanism of action is not yet fully understood.","technicalDetail":"Isothipendyl is a small molecule that binds to a specific molecular target, potentially modulating its activity and influencing downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1507","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ISOTHIPENDYL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:11:37.607837","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"isothipendyl","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003406","UNII":"WVZ7K9P0JY","CHEBI":"CHEBI:135183","INN_ID":"689","RXNORM":"235726","UMLSCUI":"C0064088","ChEMBL_ID":"CHEMBL2111066","KEGG_DRUG":"D01143","DRUGBANK_ID":"DB08802","PUBCHEM_CID":"3781","SECONDARY_CAS_RN":"1225-60-1","MESH_SUPPLEMENTAL_RECORD_UI":"C008214"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA22","allCodes":["D04AA22","R06AD09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2020 Jul","pmid":"32124458","title":"Photodermatitis from topical phenothiazines: A case series.","journal":"Contact dermatitis"},{"date":"2012","pmid":"22677929","title":"Contact photoallergy to isothipendyl chlorhydrate.","journal":"Dermatology (Basel, Switzerland)"},{"date":"2003 Jan","pmid":"14723280","title":"Spectrophotometric studies on the investigation of chromium in environmental samples.","journal":"Indian journal of environmental health"},{"date":"2003 Mar","pmid":"12675360","title":"Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations.","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"},{"date":"2001 Sep","pmid":"11708072","title":"Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples.","journal":"Analytical sciences : the international journal of the Japan Society for Analytical Chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dimethylaminoisopropylazaphenothiazine, also known as isothipendyl, is a small molecule drug of the isothipendyl class. Its mechanism of action and target are currently unknown. Isothipendyl is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are also unknown. Further research is needed to understand its potential therapeutic applications and safety considerations. As a result, key safety considerations and potential side effects are currently undefined.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}