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Together, they provide synergistic activity against Mycobacterium tuberculosis by disrupting essential cell wall components and metabolic pathways.","oneSentence":"Isoniazid and ethambutol are bactericidal and bacteriostatic agents that inhibit mycobacterial cell wall and metabolic synthesis, respectively, to treat tuberculosis infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:20.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tuberculosis (pulmonary and extrapulmonary)"}]},"trialDetails":[{"nctId":"NCT04930744","phase":"PHASE2","title":"Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2021-08-26","conditions":"Tuberculosis, Pulmonary Tuberculosis, HIV Coinfection","enrollment":112},{"nctId":"NCT06192160","phase":"PHASE2","title":"Trial of Novel Regimens for the Treatment of 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