{"id":"isomethadone","rwe":[{"pmid":"6284938","year":"1982","title":"Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that mu and delta opioid receptors possess different stereochemical requirements.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"1003408","year":"1976","title":"Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone diastereomers.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"4424428","year":"1974","title":"Crystal structures of analgesics. Hydrochlorides of (minus)-isomethadone, alpha-methadol, and alpha-methadyl acetate.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"4808459","year":"1974","title":"Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"4753665","year":"1973","title":"[Stereoselectivity of the reduction of isomethadone (author's transl)].","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"}],"tags":[{"label":"isomethadone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"isadanone","offLabel":[],"synonyms":["isometadone","isomethadone","isadanone","isoamidone"],"timeline":[],"approvals":[],"brandName":"Isadanone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"isomethadone","explanation":"Imagine your brain has special locks that control pain and feelings of well-being. Isadanone is thought to fit into these locks, which can help reduce pain and other symptoms. However, this process can also have unintended consequences, such as dependence or side effects.","oneSentence":"Isadanone is believed to work by interacting with opioid receptors in the brain.","technicalDetail":"Isadanone is a mu-opioid receptor agonist, which means it binds to and activates these receptors, producing analgesic and euphoric effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1495","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ISOMETHADONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:10:33.213311","biosimilars":[],"competitors":[],"genericName":"isomethadone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"12L95QD6KV","CHEBI":"CHEBI:135321","INN_ID":"4199","UMLSCUI":"C0064006","ChEMBL_ID":"CHEMBL2107418","PUBCHEM_CID":"10072","MESH_SUPPLEMENTAL_RECORD_UI":"C008191"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1982 Jun","pmid":"6284938","title":"Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that mu and delta opioid receptors possess different stereochemical requirements.","journal":"Journal of medicinal chemistry"},{"date":"1976 Nov","pmid":"1003408","title":"Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone diastereomers.","journal":"Journal of medicinal chemistry"},{"date":"1974 Oct","pmid":"4424428","title":"Crystal structures of analgesics. Hydrochlorides of (minus)-isomethadone, alpha-methadol, and alpha-methadyl acetate.","journal":"Journal of medicinal chemistry"},{"date":"1974 Jan","pmid":"4808459","title":"Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance.","journal":"Journal of medicinal chemistry"},{"date":"1973 Jul","pmid":"4753665","title":"[Stereoselectivity of the reduction of isomethadone (author's transl)].","journal":"Archiv der Pharmazie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isadanone, also known as Isomethadone, is a small molecule drug in the isomethadone class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with opioid receptors in the brain. Isadanone is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Key safety considerations for Isadanone are not well established due to its lack of FDA approval. Further research is needed to fully understand the properties and potential risks of this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}