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Together, these mechanisms produce rapid onset of unconsciousness, analgesia, and muscle relaxation suitable for surgical anesthesia.","oneSentence":"These volatile anesthetics enhance inhibitory GABA receptor signaling and inhibit excitatory NMDA receptor function to produce general anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:19.756Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia for surgical procedures"},{"name":"Maintenance of anesthesia during surgery"}]},"trialDetails":[{"nctId":"NCT03034096","phase":"PHASE4","title":"General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial","status":"COMPLETED","sponsor":"Stony Brook University","startDate":"2017-01-31","conditions":"Anesthesia, General, Surgical Oncology","enrollment":1826},{"nctId":"NCT05261516","phase":"PHASE4","title":"Interaction of Volatile Anesthetics With Magnesium","status":"RECRUITING","sponsor":"Christoph Czarnetzki","startDate":"2022-11-18","conditions":"Neuromuscular Blockade","enrollment":96},{"nctId":"NCT06330038","phase":"PHASE4","title":"Anesthesia and Non-small Cell Lung Cancer Recurrence","status":"NOT_YET_RECRUITING","sponsor":"Samsung Medical Center","startDate":"2024-05-01","conditions":"Non-small Cell Lung Cancer, Surgery, Anesthesia","enrollment":5384},{"nctId":"NCT04602546","phase":"NA","title":"Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)","status":"COMPLETED","sponsor":"Medtronic - MITG","startDate":"2021-02-09","conditions":"Anesthesia","enrollment":211},{"nctId":"NCT04074460","phase":"PHASE4","title":"Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study","status":"COMPLETED","sponsor":"Peter MacCallum Cancer Centre, Australia","startDate":"2017-08-27","conditions":"Cancer, Breast, Cancer Colorectal, Cancer Prostate","enrollment":169},{"nctId":"NCT04039854","phase":"PHASE4","title":"Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery","status":"UNKNOWN","sponsor":"King's College Hospital NHS Trust","startDate":"2019-11-20","conditions":"Coronary Heart Disease, Cardiovascular Diseases","enrollment":50},{"nctId":"NCT02726620","phase":"NA","title":"Decision Support for Intraoperative Low Blood Pressure","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2017-01-05","conditions":"Hypotension","enrollment":22435},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034},{"nctId":"NCT03860129","phase":"NA","title":"Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation","status":"COMPLETED","sponsor":"Ruhr University of Bochum","startDate":"2014-12-10","conditions":"Intensive Care Unit Syndrome","enrollment":30},{"nctId":"NCT00983918","phase":"NA","title":"Pain After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2009-09","conditions":"Postoperative Pain","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4247,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Isoflurane, Sevoflurane or Desflurane","genericName":"Isoflurane, Sevoflurane or Desflurane","companyName":"King's College Hospital NHS Trust","companyId":"king-s-college-hospital-nhs-trust","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These volatile anesthetics enhance inhibitory GABA receptor signaling and inhibit excitatory NMDA receptor function to produce general anesthesia. Used for General anesthesia for surgical procedures, Maintenance of anesthesia during surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}