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This combination approach aims to optimize anesthesia depth and analgesia during surgical procedures.","oneSentence":"Isoflurane provides general anesthesia by enhancing inhibitory GABAergic neurotransmission and suppressing excitatory glutamatergic signaling, while a co-administered analgesic drug provides pain relief through opioid or non-opioid pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:53.023Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia with analgesia for surgical procedures"}]},"trialDetails":[{"nctId":"NCT06970548","phase":"NA","title":"Dexamethasone As Adjuvant for Pre - emptiveTransversusAbdominus Muscle Plane Block","status":"COMPLETED","sponsor":"Sohag University","startDate":"2022-06-01","conditions":"Post Operative Pain","enrollment":40},{"nctId":"NCT04341350","phase":"PHASE3","title":"Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation","status":"RECRUITING","sponsor":"University Hospital, Brest","startDate":"2020-08-06","conditions":"Prevention of Delirium","enrollment":250},{"nctId":"NCT06873906","phase":"PHASE3","title":"Deep Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block in Pediatric Cardiac Patients Undergoing Primary Repair of Septal Defects Via Median Sternotomy","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-03-20","conditions":"Septal Defect","enrollment":45},{"nctId":"NCT05999721","phase":"NA","title":"The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery","status":"RECRUITING","sponsor":"Shai Fein","startDate":"2025-01-25","conditions":"Postoperative Pain, Pulmonary Function Tests","enrollment":100},{"nctId":"NCT03588429","phase":"PHASE3","title":"The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics","status":"COMPLETED","sponsor":"Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine","startDate":"2020-01-01","conditions":"Anesthesia","enrollment":90},{"nctId":"NCT05565664","phase":"PHASE4","title":"Ketamine Versus Magnesium as Analgesic Adjuvants in Pediatric Adenotonsillectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-11-01","conditions":"Post Operative Pain, Acute","enrollment":38},{"nctId":"NCT05276908","phase":"NA","title":"Different Volumes of Local Anesthetics in Thoracolumbar Interfascial Plane Block","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-03-03","conditions":"Postoperative Pain","enrollment":80},{"nctId":"NCT04197570","phase":"PHASE3","title":"Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial","status":"COMPLETED","sponsor":"Benaroya Research Institute","startDate":"2020-02-04","conditions":"Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result, Anesthesia","enrollment":9},{"nctId":"NCT04446403","phase":"NA","title":"Circumflex Nerve Blocks Versus Posterior Cord Nerve Blocks in Shoulder Arthroscopy","status":"UNKNOWN","sponsor":"Bassant M. Abdelhamid","startDate":"2020-06-25","conditions":"Postoperative Pain","enrollment":30},{"nctId":"NCT03803267","phase":"NA","title":"Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2019-05-01","conditions":"Colorectal Cancer","enrollment":68},{"nctId":"NCT03560427","phase":"NA","title":"Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine","status":"COMPLETED","sponsor":"Assiut University","startDate":"2018-09-10","conditions":"Acute Pain","enrollment":60},{"nctId":"NCT03549026","phase":"NA","title":"Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2018-01-05","conditions":"Acute Pain","enrollment":70},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Isoflurane + analgesic drug","genericName":"Isoflurane + analgesic drug","companyName":"University Hospital, Brest","companyId":"university-hospital-brest","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isoflurane provides general anesthesia by enhancing inhibitory GABAergic neurotransmission and suppressing excitatory glutamatergic signaling, while a co-administered analgesic drug provides pain relief through opioid or non-opioid pathways. Used for General anesthesia with analgesia for surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}