{"id":"isoconazole","rwe":[{"pmid":"41902396","year":"2026","title":"Diversity and Antifungal Susceptibility of Malassezia spp. Isolated From Brazilian Patients With Pityriasis Versicolor and Seborrheic Dermatitis.","finding":"","journal":"Mycoses","studyType":"Clinical Study"},{"pmid":"41471035","year":"2025","title":"Dermal Formulation Incorporating Isoconazole Nitrate Nanoparticles Offers High Absorption into Skin and Antimicrobial Effect Against Candida albicans.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"41350226","year":"2025","title":"Risk of Major Congenital Malformations Associated With First-Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study.","finding":"","journal":"Pharmacoepidemiology and drug safety","studyType":"Clinical Study"},{"pmid":"41273524","year":"2026","title":"Chiral Separation in Capillary Electrophoresis Using Cyclodextrins in Combination with Hydrophobic Deep Eutectic Solvents.","finding":"","journal":"Methods in molecular biology (Clifton, N.J.)","studyType":"Clinical Study"},{"pmid":"40541645","year":"2025","title":"Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma.","finding":"","journal":"Chemico-biological interactions","studyType":"Clinical Study"}],"tags":[{"label":"isoconazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Steroid 17-alpha-hydroxylase/17,20 lyase","category":"target"},{"label":"CYP17A1","category":"gene"},{"label":"IDO1","category":"gene"},{"label":"D01AC05","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["isoconazole","isoconazole nitrate"],"offLabel":[],"synonyms":["isoconazole","isoconazole nitrate"],"timeline":[],"aiSummary":"ISOCONAZOLE is a small molecule drug that targets the enzyme steroid 17-alpha-hydroxylase/17,20 lyase. It is classified as an isoconazole and is used to treat various fungal infections. However, its commercial status and approved indications are unknown. As a result, its half-life, bioavailability, and generic manufacturers are also not available. Further research is needed to determine its safety and efficacy.","approvals":[],"ecosystem":[],"mechanism":{"target":"Indoleamine 2,3-dioxygenase 1, Steroid 17-alpha-hydroxylase/17,20 lyase","targets":[{"gene":"CYP17A1","source":"DrugCentral","target":"Steroid 17-alpha-hydroxylase/17,20 lyase","protein":"Steroid 17-alpha-hydroxylase/17,20 lyase"},{"gene":"IDO1","source":"DrugCentral","target":"Indoleamine 2,3-dioxygenase 1","protein":"Indoleamine 2,3-dioxygenase 1"}],"modality":"Small Molecule","drugClass":"isoconazole","explanation":"Think of it like a traffic cop: ISOCONAZOLE blocks the enzyme that helps make certain hormones, which can help fight fungal infections. This is a complex process, but essentially, it helps reduce the production of hormones that can contribute to fungal growth.","oneSentence":"ISOCONAZOLE works by inhibiting the enzyme steroid 17-alpha-hydroxylase/17,20 lyase, which is involved in the production of steroids and other hormones.","technicalDetail":"ISOCONAZOLE specifically inhibits the activity of the CYP17 enzyme, which is responsible for catalyzing the conversion of pregnenolone to 17-hydroxypregnenolone and progesterone to 17-hydroxyprogesterone, among other reactions."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3309","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ISOCONAZOLE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ISOCONAZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:10:14.279597","biosimilars":[],"competitors":[{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"econazole","drugSlug":"econazole","fdaApproval":"1982-12-23","patentExpiry":"Aug 8, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"thiabendazole","drugSlug":"thiabendazole","fdaApproval":"1967-04-07","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tioconazole","drugSlug":"tioconazole","fdaApproval":"1983-02-18","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoconazole","drugSlug":"ketoconazole","fdaApproval":"1981-06-12","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulconazole","drugSlug":"sulconazole","fdaApproval":"1985-08-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxiconazole","drugSlug":"oxiconazole","fdaApproval":"1988-12-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sertaconazole","drugSlug":"sertaconazole","fdaApproval":"2003-12-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"fluconazole","drugSlug":"fluconazole","fdaApproval":"1990-01-29","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"luliconazole","drugSlug":"luliconazole","fdaApproval":"2013-11-14","patentExpiry":"Sep 6, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"efinaconazole","drugSlug":"efinaconazole","fdaApproval":"2014-06-06","patentExpiry":"Oct 24, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"isoconazole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-class"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-class"},{"drugId":"econazole","brandName":"econazole","genericName":"econazole","approvalYear":"1982","relationship":"same-class"},{"drugId":"thiabendazole","brandName":"thiabendazole","genericName":"thiabendazole","approvalYear":"1967","relationship":"same-class"},{"drugId":"tioconazole","brandName":"tioconazole","genericName":"tioconazole","approvalYear":"1983","relationship":"same-class"},{"drugId":"ketoconazole","brandName":"ketoconazole","genericName":"ketoconazole","approvalYear":"1981","relationship":"same-class"},{"drugId":"sulconazole","brandName":"sulconazole","genericName":"sulconazole","approvalYear":"1985","relationship":"same-class"},{"drugId":"oxiconazole","brandName":"oxiconazole","genericName":"oxiconazole","approvalYear":"1988","relationship":"same-class"},{"drugId":"sertaconazole","brandName":"sertaconazole","genericName":"sertaconazole","approvalYear":"2003","relationship":"same-class"},{"drugId":"fluconazole","brandName":"fluconazole","genericName":"fluconazole","approvalYear":"1990","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00722189","phase":"","title":"Observational Study of Efficacy and Safety of Travogen Cream and Travocort Cream in the Treatment of Mycoses","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2008-07","conditions":["Skin Mycoses"],"enrollment":900,"completionDate":"2009-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"003740","UNII":"GRI7WFR424","CHEBI":"CHEBI:82865","INN_ID":"3505","RXNORM":"203157","UMLSCUI":"C0063953","ChEMBL_ID":"CHEMBL1571863","KEGG_DRUG":"D01480","DRUGBANK_ID":"DB08943","PUBCHEM_CID":"3760","SNOMEDCT_US":"350201001","SECONDARY_CAS_RN":"24168-96-5","MESH_SUPPLEMENTAL_RECORD_UI":"C020382"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":127,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D01AC05","allCodes":["D01AC05","G01AF07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Apr","pmid":"41902396","title":"Diversity and Antifungal Susceptibility of Malassezia spp. Isolated From Brazilian Patients With Pityriasis Versicolor and Seborrheic Dermatitis.","journal":"Mycoses"},{"date":"2025 Nov 26","pmid":"41471035","title":"Dermal Formulation Incorporating Isoconazole Nitrate Nanoparticles Offers High Absorption into Skin and Antimicrobial Effect Against Candida albicans.","journal":"Pharmaceutics"},{"date":"2025 Dec","pmid":"41350226","title":"Risk of Major Congenital Malformations Associated With First-Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study.","journal":"Pharmacoepidemiology and drug safety"},{"date":"2026","pmid":"41273524","title":"Chiral Separation in Capillary Electrophoresis Using Cyclodextrins in Combination with Hydrophobic Deep Eutectic Solvents.","journal":"Methods in molecular biology (Clifton, N.J.)"},{"date":"2025 Sep 5","pmid":"40541645","title":"Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma.","journal":"Chemico-biological interactions"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ISOCONAZOLE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}