{"id":"iso-sorbide-dinitrate-iv-bolus-or-s-l","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-15","effect":"Hypotension"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Tachycardia"},{"rate":"5-10","effect":"Flushing"},{"rate":null,"effect":"Nitrate tolerance (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL495366","moleculeType":"Small molecule","molecularWeight":"242.19"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isosorbide dinitrate is bioconverted to nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle cells, causing vasodilation. This reduces venous return (preload) and systemic vascular resistance (afterload), decreasing myocardial oxygen demand and improving coronary blood flow. The drug is used acutely for anginal episodes and chronically for angina prophylaxis and heart failure management.","oneSentence":"Isosorbide dinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and reduce cardiac preload and afterload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:17.651Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute angina pectoris (sublingual)"},{"name":"Angina prophylaxis (chronic therapy)"},{"name":"Acute decompensated heart failure (intravenous)"}]},"trialDetails":[{"nctId":"NCT00337116","phase":"PHASE4","title":"Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients","status":"WITHDRAWN","sponsor":"Soroka University Medical Center","startDate":"2007-01","conditions":"Unstable Angina, Myocardial Infarction","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10996,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"iso sorbide dinitrate iv bolus or s/l","genericName":"iso sorbide dinitrate iv bolus or s/l","companyName":"Soroka University Medical Center","companyId":"soroka-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isosorbide dinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and reduce cardiac preload and afterload. Used for Acute angina pectoris (sublingual), Angina prophylaxis (chronic therapy), Acute decompensated heart failure (intravenous).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}