{"id":"islets-of-langerhans-transplantation","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft failure / loss of insulin independence"},{"rate":null,"effect":"Immunosuppression-related infections"},{"rate":null,"effect":"Immunosuppression-related malignancy"},{"rate":null,"effect":"Bleeding at transplant site"},{"rate":null,"effect":"Portal vein thrombosis"},{"rate":null,"effect":"Hyperglycemia recurrence"}]},"_chembl":{"chemblId":"CHEMBL3770173","moleculeType":"Small molecule","molecularWeight":"440.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This procedure involves isolation and transplantation of pancreatic islets (clusters of insulin-secreting beta cells) from a donor pancreas into a recipient with type 1 diabetes. The transplanted islets engraft in the recipient's liver or other sites and begin producing insulin in response to blood glucose levels, potentially eliminating the need for exogenous insulin therapy. Success requires immunosuppression to prevent rejection of the allogeneic tissue.","oneSentence":"Islet transplantation restores functional insulin-producing beta cells to the pancreas, enabling endogenous insulin secretion and glucose homeostasis in patients with type 1 diabetes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:16.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus with severe hypoglycemia unawareness or brittle diabetes"},{"name":"Type 1 diabetes with impaired kidney function (simultaneous pancreatic islet and kidney transplant)"}]},"trialDetails":[{"nctId":"NCT07228195","phase":"PHASE4","title":"SGLT2i Therapy in Islet Transplantation (SIT)","status":"NOT_YET_RECRUITING","sponsor":"University of Minnesota","startDate":"2026-05-15","conditions":"Partial Islet Function, TPIAT, Diabetes","enrollment":40},{"nctId":"NCT03835312","phase":"NA","title":"Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM","status":"RECRUITING","sponsor":"Children's Hospital of Fudan University","startDate":"2019-02-20","conditions":"Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes","enrollment":50},{"nctId":"NCT07470593","phase":"","title":"Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.","status":"RECRUITING","sponsor":"University Hospital, Strasbourg, France","startDate":"2025-12-15","conditions":"Type 1 Diabetes (T1D)","enrollment":36},{"nctId":"NCT02846571","phase":"PHASE1, PHASE2","title":"Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye","status":"RECRUITING","sponsor":"Midhat H. 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With Unstable Type 1 Diabetes","status":"RECRUITING","sponsor":"University Hospital, Grenoble","startDate":"2025-06-04","conditions":"Type 1 Diabetes (T1D)","enrollment":35},{"nctId":"NCT05349591","phase":"PHASE1","title":"cePolyTregs in Islet Transplantation","status":"WITHDRAWN","sponsor":"University of Alberta","startDate":"2022-08-15","conditions":"Diabetes type1","enrollment":""},{"nctId":"NCT06991829","phase":"EARLY_PHASE1","title":"Clinical Study on the Safety and Efficacy of Immunophenotyped Pancreatic Endocrine Organoid Bank in Treating Patients With T3c Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2025-04-03","conditions":"Diabetes Mellitus","enrollment":29},{"nctId":"NCT03073577","phase":"PHASE1","title":"Islet Transplantation Using PKX-001","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2017-02-17","conditions":"Type 1 Diabetes 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Indication for Islet Autotransplantation in Pancreatic Surgery","status":"UNKNOWN","sponsor":"Ospedale San Raffaele","startDate":"2012-02","conditions":"Diabetes","enrollment":150},{"nctId":"NCT06196996","phase":"NA","title":"Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus","status":"RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2021-09-14","conditions":"Brittle Type 1 Diabetes Mellitus","enrollment":18},{"nctId":"NCT01817959","phase":"PHASE3","title":"Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2012-10","conditions":"Islet Transplantation in Diabetes Mellitus Type 1","enrollment":51},{"nctId":"NCT02464878","phase":"PHASE2","title":"Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant","status":"COMPLETED","sponsor":"Massachusetts General 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Transplantation","enrollment":24},{"nctId":"NCT05990517","phase":"PHASE2","title":"Autologous Transplantation of Expanded Pancreatic Islet Cells (YD01-2022) in Patients","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2023-02-22","conditions":"Diabetes After Total Pancreatectomy","enrollment":3},{"nctId":"NCT05990530","phase":"PHASE2","title":"Allogeneic Transplantation of Expanded Pancreatic Islet Cells","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2023-02-22","conditions":"Brittle Type 1 Diabetes","enrollment":6},{"nctId":"NCT02402439","phase":"PHASE1","title":"Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol","status":"UNKNOWN","sponsor":"Andrew Posselt","startDate":"2016-03","conditions":"Diabetes Mellitus, Type 1","enrollment":3},{"nctId":"NCT05977205","phase":"","title":"COVID-19 Glycemic Control Study","status":"COMPLETED","sponsor":"Leiden University Medical Center","startDate":"2020-05-02","conditions":"Type 1 Diabetes, Type 2 Diabetes","enrollment":492},{"nctId":"NCT04629586","phase":"","title":"The T1D Exchange Registry","status":"RECRUITING","sponsor":"T1D Exchange, United States","startDate":"2018-12-13","conditions":"Diabetes Mellitus, Type 1, Diabetes, Type 1 Diabetes","enrollment":50000},{"nctId":"NCT05480657","phase":"PHASE1, PHASE2","title":"Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D","status":"WITHDRAWN","sponsor":"Eledon Pharmaceuticals","startDate":"2022-09-30","conditions":"Brittle Type 1 Diabetes Mellitus","enrollment":""},{"nctId":"NCT05662267","phase":"","title":"Kidney Alone Versus Islet-After-Kidney in Type 1 Diabetic Kidney Transplant Recipient.","status":"UNKNOWN","sponsor":"University Hospital, Lille","startDate":"2020-03-10","conditions":"type1diabetes, Renal Failure, End Stage Renal 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Therapy","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2014-11-03","conditions":"Islet Transplantation","enrollment":45},{"nctId":"NCT01653899","phase":"PHASE1, PHASE2","title":"Caspase Inhibition in Islet Transplantation","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2012-06","conditions":"Diabetes","enrollment":12},{"nctId":"NCT03283566","phase":"PHASE2","title":"Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2017-10-03","conditions":"Chronic Pancreatitis, Insulin Dependent Diabetes","enrollment":9},{"nctId":"NCT02384018","phase":"PHASE1","title":"Mesenchymal Stem Cell and Islet Co-transplantation","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2014-12","conditions":"Chronic Pancreatitis, Diabetes","enrollment":3},{"nctId":"NCT05294822","phase":"NA","title":"Autologous Regenerative Islet Transplantation for Insulin-dependent Diabetes","status":"UNKNOWN","sponsor":"Shanghai Changzheng Hospital","startDate":"2019-09-30","conditions":"Diabetes","enrollment":20},{"nctId":"NCT03785236","phase":"","title":"Visualizing Beta Cells After Islet Transplantation","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2016-06-06","conditions":"Type 1 Diabetes Mellitus","enrollment":13},{"nctId":"NCT00789308","phase":"PHASE2","title":"Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2008-07-11","conditions":"Diabetes Mellitus, Type I","enrollment":24},{"nctId":"NCT04884633","phase":"NA","title":"Novel Method of Pancreatic Islet Transplantation Into the Omentum","status":"UNKNOWN","sponsor":"Frantisek Saudek","startDate":"2019-08-15","conditions":"Islets of Langerhans Transplantation","enrollment":6},{"nctId":"NCT01050166","phase":"","title":"MRI Imaging of Labeled Human Islets Transplanted Into the Liver","status":"COMPLETED","sponsor":"Frantisek Saudek","startDate":"2008-08-15","conditions":"Type 1 Diabetes Mellitus","enrollment":8},{"nctId":"NCT00006505","phase":"PHASE2","title":"Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2000-11-16","conditions":"Diabetes Mellitus Type 1","enrollment":6},{"nctId":"NCT00566813","phase":"PHASE1, PHASE2","title":"Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2004-11","conditions":"Diabetes Mellitus, Type 1","enrollment":10},{"nctId":"NCT01548729","phase":"PHASE1, PHASE2","title":"Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2012-02-25","conditions":"Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes","enrollment":14},{"nctId":"NCT04820270","phase":"NA","title":"Infusion of Autologous T Regulatory Cells (T Reg) at the Time of Transplantation of Allogenic Islets of Langerhans","status":"UNKNOWN","sponsor":"The Nordic Network For Clinical Islet Transplantation","startDate":"2018-08-20","conditions":"Type1diabetes","enrollment":8},{"nctId":"NCT01220856","phase":"PHASE2","title":"Reparixin in Pancreatic Islet Transplantation","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2010-07-28","conditions":"Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus","enrollment":9},{"nctId":"NCT04487197","phase":"","title":"SARS-CoV2 (COVID-19) Seroepidemiological Transplanted 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