{"id":"islet-graft","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft rejection"},{"rate":null,"effect":"Immunosuppression-related infections"},{"rate":null,"effect":"Portal vein thrombosis"},{"rate":null,"effect":"Bleeding at infusion site"},{"rate":null,"effect":"Hyperglycemia (graft failure)"}]},"_chembl":{"chemblId":"CHEMBL2109025","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pancreatic islets containing insulin-secreting beta cells are isolated from a donor pancreas and infused into the recipient's liver via the portal vein, where they engraft and begin producing insulin in response to blood glucose levels. This approach aims to restore physiologic glucose regulation and reduce or eliminate the need for exogenous insulin therapy. The procedure requires immunosuppression to prevent rejection of the allogeneic tissue.","oneSentence":"Islet graft restores insulin-producing beta cell function by transplanting isolated pancreatic islets to replace lost endocrine tissue in patients with type 1 diabetes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:17.161Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus with severe hypoglycemia unawareness or brittle diabetes"}]},"trialDetails":[{"nctId":"NCT02000687","phase":"","title":"Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss","status":"RECRUITING","sponsor":"Rodolfo Alejandro","startDate":"2008-12","conditions":"Type 1 Diabetes Mellitus","enrollment":60},{"nctId":"NCT01999361","phase":"NA","title":"Prevention of de Novo Allosensitization in Islet Transplant Recipients Following Complete Graft Loss","status":"RECRUITING","sponsor":"Rodolfo Alejandro","startDate":"2009-01","conditions":"Type 1 Diabetes Mellitus","enrollment":18},{"nctId":"NCT07470593","phase":"","title":"Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.","status":"RECRUITING","sponsor":"University Hospital, Strasbourg, France","startDate":"2025-12-15","conditions":"Type 1 Diabetes (T1D)","enrollment":36},{"nctId":"NCT06305286","phase":"PHASE1, PHASE2","title":"Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2024-03-04","conditions":"Type 1 Diabetes Mellitus","enrollment":70},{"nctId":"NCT06575426","phase":"PHASE1, PHASE2","title":"A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 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Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2017-01-20","conditions":"Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness","enrollment":11},{"nctId":"NCT01705899","phase":"PHASE1","title":"Islet Allotransplantation in Type 1 Diabetes","status":"SUSPENDED","sponsor":"Ohio State University","startDate":"2006-11","conditions":"Type 1 Diabetes","enrollment":20},{"nctId":"NCT02803905","phase":"PHASE2","title":"Islet Transplant Alone in OMENtum","status":"UNKNOWN","sponsor":"Lorenzo Piemonti","startDate":"2016-04","conditions":"Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1","enrollment":12},{"nctId":"NCT01817959","phase":"PHASE3","title":"Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2012-10","conditions":"Islet Transplantation in Diabetes Mellitus Type 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Mellitus","enrollment":""},{"nctId":"NCT02854696","phase":"PHASE3","title":"Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes","status":"UNKNOWN","sponsor":"University Hospital, Grenoble","startDate":"2016-07-07","conditions":"Type 1 Diabetes","enrollment":42},{"nctId":"NCT02821026","phase":"PHASE1, PHASE2","title":"Omental Islet Transplant","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2016-05","conditions":"Type 1 Diabetes","enrollment":4},{"nctId":"NCT02627690","phase":"","title":"Nephrologic Prognosis 10 Years After Diabetes Cell Therapy","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2014-11-03","conditions":"Islet Transplantation","enrollment":45},{"nctId":"NCT01050166","phase":"","title":"MRI Imaging of Labeled Human Islets Transplanted Into the Liver","status":"COMPLETED","sponsor":"Frantisek Saudek","startDate":"2008-08-15","conditions":"Type 1 Diabetes 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Islet Transplantation","status":"TERMINATED","sponsor":"University of British Columbia","startDate":"2009-07","conditions":"Islet Transplantation","enrollment":12},{"nctId":"NCT01206101","phase":"PHASE2","title":"Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation","status":"TERMINATED","sponsor":"Novo Nordisk A/S","startDate":"2012-03-21","conditions":"Diabetes, Diabetes Mellitus, Type 1","enrollment":3},{"nctId":"NCT00276250","phase":"PHASE2","title":"Islet Transplantation Using Abatacept","status":"COMPLETED","sponsor":"Emory University","startDate":"2005-12","conditions":"Type 1 Diabetes Mellitus","enrollment":5},{"nctId":"NCT00464555","phase":"PHASE2","title":"Strategies to Improve Islet Survival","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2006-12","conditions":"Type 1 Diabetes Mellitus","enrollment":5},{"nctId":"NCT00768651","phase":"PHASE2","title":"Incretin 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Used for Type 1 diabetes mellitus with severe hypoglycemia unawareness or brittle diabetes.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}