{"id":"isis-ptp1brx","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Liver enzyme elevation"},{"rate":null,"effect":"Platelet reduction"}]},"_chembl":{"chemblId":"CHEMBL499450","moleculeType":"Small molecule","molecularWeight":"7343.20"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"PTP1B is a negative regulator of insulin receptor signaling; by reducing PTP1B expression, the drug enhances insulin sensitivity and glucose uptake in target tissues. This mechanism is intended to improve glycemic control and metabolic parameters in metabolic diseases. The antisense approach allows selective reduction of the target protein without affecting other pathways.","oneSentence":"ISIS-PTP1BRx is an antisense oligonucleotide that inhibits protein tyrosine phosphatase 1B (PTP1B) to improve insulin signaling and glucose metabolism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:56:43.902Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Obesity"}]},"trialDetails":[{"nctId":"NCT01918865","phase":"PHASE2","title":"Safety, Tolerability, and Efficacy of ISIS-PTP1BRx in Type 2 Diabetes","status":"COMPLETED","sponsor":"Ionis Pharmaceuticals, Inc.","startDate":"2013-08","conditions":"Type 2 Diabetes Mellitus, Obese","enrollment":92}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"ISIS-PTP1BRx","genericName":"ISIS-PTP1BRx","companyName":"Ionis Pharmaceuticals, Inc.","companyId":"ionis-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ISIS-PTP1BRx is an antisense oligonucleotide that inhibits protein tyrosine phosphatase 1B (PTP1B) to improve insulin signaling and glucose metabolism. Used for Type 2 diabetes mellitus, Obesity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}