{"id":"irradiated-rbc","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion-related reactions"},{"rate":null,"effect":"Immune activation-related events"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Irradiated autologous or allogeneic RBCs are treated with radiation to induce immunogenic cell death, which exposes damage-associated molecular patterns (DAMPs) and tumor-associated antigens. This triggers innate and adaptive immune responses, potentially enhancing anti-tumor immunity. The approach is designed to prime the immune system against malignant cells.","oneSentence":"Irradiated red blood cells act as an immunogenic cellular vaccine to stimulate anti-tumor immune responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:17:16.251Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pediatric hematologic malignancies (phase 3 development)"}]},"trialDetails":[{"nctId":"NCT03910452","phase":"EARLY_PHASE1","title":"Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2019-10-28","conditions":"Chronic Granulomatous Disease","enrollment":4},{"nctId":"NCT06872333","phase":"PHASE2","title":"Allo HSCT for High Risk Hemoglobinopathies","status":"RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2024-11-19","conditions":"Graft Failure, Sickle Cell Disease, Hemoglobinopathies","enrollment":62},{"nctId":"NCT07446647","phase":"PHASE1","title":"Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion","status":"NOT_YET_RECRUITING","sponsor":"Jose Cancelas","startDate":"2026-03","conditions":"Healthy Volunteer Red Blood Cell Labeling Study; 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