{"id":"iron-therapy","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Gastrointestinal upset (nausea, constipation, abdominal discomfort)"},{"rate":null,"effect":"Dark stools"},{"rate":"5-15","effect":"Epigastric pain"},{"rate":"5-10","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":{"setId":"d74df3b2-dea7-4ed2-b30a-ec7f40d1a70f","title":"IRON THERAPY (CHININUM ARSENICOSUM, CUPRUM SULPHURICUM, FERRUM METALLICUM, FERRUM PHOSPHORICUM, ZINCUM METALLICUM) TABLET [NUTREXIN USA]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iron is an essential component of hemoglobin, the oxygen-carrying protein in red blood cells. When iron stores are depleted, the body cannot produce sufficient hemoglobin, leading to anemia. Iron supplementation replenishes these stores, enabling normal erythropoiesis and restoration of oxygen-carrying capacity.","oneSentence":"Iron therapy replaces depleted iron stores to restore hemoglobin synthesis and correct iron deficiency anemia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:14.144Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Iron deficiency anemia"},{"name":"Iron supplementation in pregnancy"},{"name":"Iron deficiency due to chronic blood loss"}]},"trialDetails":[{"nctId":"NCT00007150","phase":"PHASE2","title":"Treatment of Hemochromatosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institutes of Health Clinical Center (CC)","startDate":"2001-01-01","conditions":"Hemochromatosis","enrollment":622},{"nctId":"NCT04404881","phase":"PHASE2","title":"Bevacizumab In Hereditary Hemorrhagic Telangiectasia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hanny Al-Samkari, MD","startDate":"2020-11-23","conditions":"Hereditary Hemorrhagic Telangiectasia","enrollment":33},{"nctId":"NCT06435546","phase":"NA","title":"Adherence to Oral Therapies in Advanced Breast and Prostate Cancers","status":"COMPLETED","sponsor":"Institut de Cancérologie de Lorraine","startDate":"2024-06-04","conditions":"Breast Cancer, Prostate Cancer","enrollment":200},{"nctId":"NCT05385042","phase":"NA","title":"Iron and Immune Response to Vaccine (IRONMUM)","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2022-06-18","conditions":"Pregnancy Related","enrollment":171},{"nctId":"NCT07476859","phase":"PHASE4","title":"Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome","status":"RECRUITING","sponsor":"Fundación para la Investigación del Hospital Clínico de Valencia","startDate":"2026-03-05","conditions":"Acute Coronary Syndromes (ACS), Iron Deficiencies, Elderly (People Aged 65 or More)","enrollment":538},{"nctId":"NCT07491783","phase":"PHASE2","title":"Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical Trial","status":"NOT_YET_RECRUITING","sponsor":"Sichuan Enray Pharmaceutical Sciences Company","startDate":"2026-03-27","conditions":"HNSCC, Soft Tissue Cancer","enrollment":52},{"nctId":"NCT07485023","phase":"NA","title":"Oral Versus Intravenous Iron for Anemia Diagnosed After 34 Weeks of Gestation","status":"NOT_YET_RECRUITING","sponsor":"University of Roma La Sapienza","startDate":"2026-07-01","conditions":"Anemia Complicating Pregnancy","enrollment":128},{"nctId":"NCT06421636","phase":"PHASE2","title":"A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body","status":"RECRUITING","sponsor":"Regeneron Pharmaceuticals","startDate":"2024-09-30","conditions":"Non-Transfusion Dependent Beta-Thalassemia (NTDT)","enrollment":95},{"nctId":"NCT06884280","phase":"PHASE3","title":"Comparing High and Low Dose Iron Treatments for People on Peritoneal Dialysis: The PALaDIN Study","status":"RECRUITING","sponsor":"Hull University Teaching Hospitals NHS Trust","startDate":"2025-11-13","conditions":"Peritoneal Dialysis, Anaemia, Iron Deficiency, Anaemia","enrollment":30},{"nctId":"NCT07467668","phase":"NA","title":"Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Kaiser Permanente","startDate":"2026-03-09","conditions":"Iron Deficiency (ID), Heart Failure, Heart Failure and Reduced Ejection Fraction","enrollment":3000},{"nctId":"NCT03725150","phase":"","title":"Treatment of Iron Deficiency Anaemia in Pregnancy Study","status":"COMPLETED","sponsor":"The Royal Wolverhampton Hospitals NHS Trust","startDate":"2018-06-19","conditions":"Anemia, Iron Deficiency","enrollment":120},{"nctId":"NCT04040023","phase":"NA","title":"Patient Blood Management in Cardiac Surgery","status":"COMPLETED","sponsor":"Clinique Pasteur","startDate":"2019-09-10","conditions":"Surgical Blood Loss","enrollment":900},{"nctId":"NCT06781099","phase":"NA","title":"Feasibility Trial of Extracorporeal Iron Purification in Patients With Myelodysplastic Syndrome or Myelofibrosis","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2026-01-06","conditions":"Myelodysplastic Syndrome, Myelofibrosis","enrollment":13},{"nctId":"NCT07447531","phase":"NA","title":"T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas","status":"RECRUITING","sponsor":"John M. 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