{"id":"irinotecan-liposomal-injection-onivyde","safety":{"commonSideEffects":[{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Anemia"},{"rate":null,"effect":"Thrombocytopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Irinotecan inhibits topoisomerase I, an enzyme required for DNA replication and transcription. The liposomal formulation improves drug delivery to tumors and reduces systemic toxicity compared to conventional irinotecan. This allows for better accumulation in cancer cells while minimizing exposure to healthy tissues.","oneSentence":"Irinotecan liposomal injection is a topoisomerase I inhibitor encapsulated in liposomes that prevents DNA unwinding and causes cancer cell death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:13.142Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic pancreatic cancer (in combination with 5-fluorouracil and leucovorin)"},{"name":"Metastatic colorectal cancer"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["nal-IRI","Nal-IRI"],"phase":"phase_3","status":"active","brandName":"Irinotecan Liposomal Injection [Onivyde]","genericName":"Irinotecan Liposomal Injection [Onivyde]","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Irinotecan liposomal injection is a topoisomerase I inhibitor encapsulated in liposomes that prevents DNA unwinding and causes cancer cell death. Used for Metastatic pancreatic cancer (in combination with 5-fluorouracil and leucovorin), Metastatic colorectal cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}