{"id":"irbd","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"iRBD appears to be a diagnostic or monitoring tool rather than a pharmacological agent, likely combining imaging, behavioral assessment, and data analytics to evaluate RBD symptoms and progression. The exact mechanistic details of how it functions are not well-established in publicly available literature.","oneSentence":"iRBD is an integrated rapid behavioral diagnostic system designed to assess and monitor rapid eye movement sleep behavior disorder through automated analysis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:50:14.751Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rapid eye movement sleep behavior disorder (RBD) diagnosis and monitoring"}]},"trialDetails":[{"nctId":"NCT07498452","phase":"","title":"Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others","status":"RECRUITING","sponsor":"Universita di Verona","startDate":"2025-05-06","conditions":"REM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder","enrollment":150},{"nctId":"NCT07474779","phase":"NA","title":"Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging","status":"NOT_YET_RECRUITING","sponsor":"University of Pavia","startDate":"2026-02","conditions":"Parkinson's Disease (PD), GBA1 Parkinson Disease, REM Sleep Behavior Disorder (iRBD)","enrollment":160},{"nctId":"NCT07365566","phase":"NA","title":"Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder","status":"RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2026-02-01","conditions":"REM Sleep Behavior Disorder (iRBD), Narcolepsy Type 1","enrollment":24},{"nctId":"NCT07355842","phase":"NA","title":"Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder","status":"RECRUITING","sponsor":"University of Zurich","startDate":"2026-01-15","conditions":"Parkinson Disease, REM Sleep Behavior Disorder (iRBD)","enrollment":80},{"nctId":"NCT07324330","phase":"NA","title":"Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity","status":"RECRUITING","sponsor":"University Hospital, Bonn","startDate":"2025-12-04","conditions":"Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases","enrollment":130},{"nctId":"NCT04534023","phase":"PHASE2","title":"A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ruijin Hospital","startDate":"2020-08-31","conditions":"Rapid Eye Movement Sleep Behavior Disorder, Synucleinopathy","enrollment":28},{"nctId":"NCT05471960","phase":"NA","title":"Neuroplasticity in RBD","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2022-08-01","conditions":"REM Sleep Behavior Disorder","enrollment":86},{"nctId":"NCT02305147","phase":"","title":"Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease","status":"RECRUITING","sponsor":"Institut National de la Santé Et de la Recherche Médicale, France","startDate":"2014-11-06","conditions":"Parkinson 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Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2018-05-06","conditions":"REM Sleep Behavior Disorder","enrollment":441},{"nctId":"NCT04048603","phase":"","title":"Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2019-05-15","conditions":"REM Sleep Behavior Disorder, Neurodegeneration","enrollment":182},{"nctId":"NCT03353207","phase":"","title":"Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2017-10-30","conditions":"REM Sleep Behavior Disorder, Neurodegenerative Diseases","enrollment":50},{"nctId":"NCT03255642","phase":"NA","title":"Efficacy and Safety of Melatonin and Clonazepam for IRBD","status":"COMPLETED","sponsor":"Kyung Hee University Hospital at Gangdong","startDate":"2017-11-09","conditions":"REM Sleep Behavior Disorder","enrollment":34},{"nctId":"NCT01358474","phase":"","title":"Detecting Dopaminergic Deficits in Individuals At-risk for Parkinsonism","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2011-07","conditions":"Parkinson Disease, Gaucher Disease, Idiopathic Rapid Eye Movement Sleep Disorder","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":781,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"iRBD","genericName":"iRBD","companyName":"Beijing Friendship Hospital","companyId":"beijing-friendship-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"iRBD is an integrated rapid behavioral diagnostic system designed to assess and monitor rapid eye movement sleep behavior disorder through automated analysis. Used for Rapid eye movement sleep behavior disorder (RBD) diagnosis and monitoring.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}